HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: S10A4 (P26447)
Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)
Gene: S100A4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	30083275
Identification Methods	cross-linking study, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1342 Hs			1 101
+	Hs
		641545 ERBB3_HUMAN (1-1342): 0: 1390: 100.00		S10AA_HUMAN (1-90): 7.55e-33: 111: 36.67
+	Hs
		407578 ERBB3_HUMAN (1-1342): 0: 1390: 100.00		S100B_HUMAN (3-91): 4.85e-32: 109: 47.19
+	Hs
		686814 ERBB4_HUMAN (1-1162): 0: 1154: 50.94		S10A4_HUMAN (1-101): 5.67e-40: 129: 100.00
+	Hs
		731770 ERBB4_HUMAN (1-1162): 0: 1154: 50.94		S10AB_HUMAN (2-97): 1.43e-37: 123: 27.84
+	Hs
		954956 ERBB4_HUMAN (1-1162): 0: 1154: 50.94		S10AA_HUMAN (1-90): 7.55e-33: 111: 36.67
+	Hs
		410657 ERBB2_HUMAN (25-1222): 0: 1075: 39.95		S10AB_HUMAN (2-97): 1.43e-37: 123: 27.84
+	Hs
		362800 EGFR_HUMAN (18-1211): 0: 1060: 40.65		S10A4_HUMAN (1-101): 5.67e-40: 129: 100.00
+	Hs
		362851 EGFR_HUMAN (18-1211): 0: 1060: 40.65		S10AB_HUMAN (2-97): 1.43e-37: 123: 27.84
+	Hs
		363528 EGFR_HUMAN (18-1211): 0: 1060: 40.65		HORN_HUMAN (1-96): 4.87e-33: 122: 25.74
+	Hs
		363070 EGFR_HUMAN (18-1211): 0: 1060: 40.65		S10AA_HUMAN (1-90): 7.55e-33: 111: 36.67
+	Hs
		410998 ERBB2_HUMAN (25-1222): 0: 1075: 39.95		S10AG_HUMAN (3-83): 4.09e-24: 89.5: 37.81
+	Hs
		362598 EGFR_HUMAN (18-1211): 0: 1060: 40.65		S10A9_HUMAN (3-91): 2.19e-29: 102: 31.11
+	Hs
		411066 ERBB2_HUMAN (25-1222): 0: 1075: 39.95		S10AE_HUMAN (3-84): 9.42e-21: 81: 28.05
+	Hs
		362840 EGFR_HUMAN (18-1211): 0: 1060: 40.65		S10A7_HUMAN (3-93): 7.13e-20: 78.7: 23.66
+	Hs
		444884 RET_HUMAN (518-1072): 5.32e-118: 397: 21.15		S10A9_HUMAN (3-91): 2.19e-29: 102: 31.11
+	Hs
		424126 INSRR_HUMAN (330-644): 1.2e-16: 88.3: 14.55		S10A8_HUMAN (1-88): 2e-25: 92.6: 29.55