HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: S10AB (P31949)
Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]
Gene: S100A11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0007165 - signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 105
+	Hs
		410998 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		S10AG_HUMAN (8-101): 8.99e-27: 96.5: 25.26
+	Hs
		411066 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		S10AE_HUMAN (8-89): 3.84e-22: 84.6: 28.05
+	Hs
		731770 ERBB4_HUMAN (6-1232): 0: 1103: 45.86		S10AB_HUMAN (1-105): 3.5e-45: 143: 100.00
+	Hs
		954956 ERBB4_HUMAN (6-1232): 0: 1103: 45.86		S10AA_HUMAN (7-104): 3.71e-37: 122: 34.69
+	Hs
		362851 EGFR_HUMAN (16-1253): 0: 1078: 48.80		S10AB_HUMAN (1-105): 3.5e-45: 143: 100.00
+	Hs
		686814 ERBB4_HUMAN (6-1232): 0: 1103: 45.86		S10A4_HUMAN (9-103): 1.56e-34: 116: 28.42
+	Hs
		363528 EGFR_HUMAN (16-1253): 0: 1078: 48.80		HORN_HUMAN (9-104): 6.12e-34: 125: 27.00
+	Hs
		363070 EGFR_HUMAN (16-1253): 0: 1078: 48.80		S10AA_HUMAN (7-104): 3.71e-37: 122: 34.69
+	Hs
		362800 EGFR_HUMAN (16-1253): 0: 1078: 48.80		S10A4_HUMAN (9-103): 1.56e-34: 116: 28.42
+	Hs
		362598 EGFR_HUMAN (16-1253): 0: 1078: 48.80		S10A9_HUMAN (8-98): 1.63e-32: 111: 35.87
+	Hs
		641545 ERBB3_HUMAN (5-1252): 0: 1047: 38.79		S10AA_HUMAN (7-104): 3.71e-37: 122: 34.69
+	Hs
		362840 EGFR_HUMAN (16-1253): 0: 1078: 48.80		S10A7_HUMAN (6-100): 5.18e-24: 89.2: 32.99
+	Hs
		641487 ERBB3_HUMAN (5-1252): 0: 1047: 38.79		S10A4_HUMAN (9-103): 1.56e-34: 116: 28.42
+	Hs
		407578 ERBB3_HUMAN (5-1252): 0: 1047: 38.79		S100B_HUMAN (8-95): 1.51e-32: 110: 36.36
+	Hs
		444884 RET_HUMAN (426-1088): 1.34e-129: 428: 23.46		S10A9_HUMAN (8-98): 1.63e-32: 111: 35.87
+	Hs
		658714 JAK1_HUMAN (669-1035): 3.64e-43: 174: 19.38		FILA2_HUMAN (8-103): 2.04e-29: 111: 40.00
+	Hs
		407581 JAK1_HUMAN (669-1035): 3.64e-43: 174: 19.38		S100B_HUMAN (8-95): 1.51e-32: 110: 36.36
+	Hs
		424126 INSRR_HUMAN (359-636): 6.25e-16: 85.6: 21.92		S10A8_HUMAN (8-102): 2.48e-29: 102: 26.32