HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: RHG25 (P42331)
Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25)
Gene: ARHGAP25

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	39358380
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 645
+	Hs
		362816 EGFR_HUMAN (1-1210): 0: 1246: 100.00		P85A_HUMAN (78-637): 1.56e-87: 289: 14.66
+	Hs
		73981 EGFR_HUMAN (1-1210): 0: 1246: 100.00		MYO9A_HUMAN (57-615): 1.43e-72: 257: 15.84
+	Hs
		67596 EGFR_HUMAN (1-1210): 0: 1246: 100.00		RHG32_HUMAN (109-554): 1.08e-69: 249: 18.91
+	Hs
		136243 EGFR_HUMAN (1-1210): 0: 1246: 100.00		P85B_HUMAN (158-636): 1.16e-71: 247: 14.66
+	Hs
		363179 EGFR_HUMAN (1-1210): 0: 1246: 100.00		RHG01_HUMAN (123-361): 1.25e-65: 223: 23.72
+	Hs
		699758 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		P85A_HUMAN (78-637): 1.56e-87: 289: 14.66
+	Mm
		686949 ERBB2_MOUSE (5-1203): 0: 1131: 48.34		P85A_MOUSE (78-637): 5.26e-85: 283: 14.49
+	Hs
		410642 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		P85A_HUMAN (78-637): 1.56e-87: 289: 14.66
+	Hs
		136389 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		P85B_HUMAN (158-636): 1.16e-71: 247: 14.66
+	Hs
		641490 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		P85A_HUMAN (78-637): 1.56e-87: 289: 14.66
+	Hs
		73984 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		MYO9A_HUMAN (57-615): 1.43e-72: 257: 15.84
+	Hs
		136250 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		P85B_HUMAN (158-636): 1.16e-71: 247: 14.66
+	Hs
		136291 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		P85B_HUMAN (158-636): 1.16e-71: 247: 14.66
+	Hs
		410585 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		CHIN_HUMAN (151-353): 1.76e-67: 229: 26.70
+	Hs
		641537 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		CHIO_HUMAN (156-353): 1.07e-68: 233: 26.87
+	Hs
		463905 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		P85A_HUMAN (78-637): 1.56e-87: 289: 14.66
+	Mm
		686937 RET_MOUSE (420-1058): 1.07e-127: 421: 23.08		P85A_MOUSE (78-637): 5.26e-85: 283: 14.49
+	Hs
		136261 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		P85B_HUMAN (158-636): 1.16e-71: 247: 14.66
+	Hs
		67621 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		RHG32_HUMAN (109-554): 1.08e-69: 249: 18.91
+	Hs
		136302 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		P85B_HUMAN (158-636): 1.16e-71: 247: 14.66