HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	25402006, 24658140, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, ubiquitin reconstruction, luminescence based mammalian interactome mapping
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 533
+	Hs
		1094302 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		LCP2_HUMAN (1-533): 2.39e-78: 257: 100.00
+	Hs
		363503 EGFR_HUMAN (1-1210): 0: 1246: 100.00		CLNK_HUMAN (182-528): 9.86e-42: 156: 25.00
+	Rn
		98572 Q9QX70_RAT (1-1210): 0: 1250: 90.34		F1LN91_RAT (104-512): 5.26e-34: 139: 13.00
+	Hs
		363625 EGFR_HUMAN (1-1210): 0: 1246: 100.00		BLNK_HUMAN (75-520): 1.01e-33: 135: 24.28
+	Hs
		410805 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		LCP2_HUMAN (1-533): 2.39e-78: 257: 100.00
+	Hs
		363411 EGFR_HUMAN (1-1210): 0: 1246: 100.00		TENS2_HUMAN (76-512): 1.92e-30: 128: 17.42
+	Hs
		363413 EGFR_HUMAN (1-1210): 0: 1246: 100.00		TENS3_HUMAN (83-512): 2.88e-29: 125: 12.50
+	Hs
		363552 EGFR_HUMAN (1-1210): 0: 1246: 100.00		TENS4_HUMAN (189-512): 1.18e-26: 116: 16.52
+	Hs
		363883 EGFR_HUMAN (1-1210): 0: 1246: 100.00		TENS1_HUMAN (85-512): 6.08e-23: 105: 14.61
+	Hs
		363641 EGFR_HUMAN (1-1210): 0: 1246: 100.00		TITIN_HUMAN (65-384): 2.15e-11: 69.3: 12.27
+	Hs
		362705 EGFR_HUMAN (1-1210): 0: 1246: 100.00		MUC1_HUMAN (191-473): 9.08e-09: 60.4: 10.88
+	Hs
		1145741 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		TENS2_HUMAN (76-512): 1.92e-30: 128: 17.42
+	Hs
		1145742 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		TENS3_HUMAN (83-512): 2.88e-29: 125: 12.50
+	Hs
		410922 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		CLNK_HUMAN (182-528): 9.86e-42: 156: 25.00
+	Hs
		1145748 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		TENS4_HUMAN (189-512): 1.18e-26: 116: 16.52
+	Hs
		1145782 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		TENS1_HUMAN (85-512): 6.08e-23: 105: 14.61
+	Hs
		410896 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		TENS2_HUMAN (76-512): 1.92e-30: 128: 17.42
+	Hs
		410898 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		TENS3_HUMAN (83-512): 2.88e-29: 125: 12.50
+	Hs
		590283 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		MUC1_HUMAN (191-473): 9.08e-09: 60.4: 10.88
+	Hs
		410586 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		MUC1_HUMAN (191-473): 9.08e-09: 60.4: 10.88