Protein: LCP2
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)

Gene: LCP2
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q13094

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005911 - cell-cell junction
GO:0006955 - immune response
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
GO:0035556 - intracellular signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

292831

GRAP2
GRB2-related adapter protein 2

20

20

Small-scale

0.991

High

987600

GRB2
Growth factor receptor-bound protein 2

16

20

Small-scale

0.985

High

178087

FYB1
FYN-binding protein 1

9

9

Small-scale

0.968

High

593980

NCK1
SH2/SH3 adapter protein NCK1

8

20

Small-scale

0.967

High

1065076

ITK
Tyrosine-protein kinase ITK/TSK

6

20

Small-scale

0.938

High

584529

VAV
Proto-oncogene vav

6

17

Small-scale

0.936

High

619045

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

5

4

Small-scale

0.936

High

222071

NCK2
Cytoplasmic protein NCK2

4

20

High-throughput

0.914

High

296491

STAM2
Signal transducing adapter molecule 2

4

19

Small-scale

0.905

High

363209

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.867

High

699727

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

6

Small-scale

0.863

High

711115

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

2

Small-scale

0.812

High

849064

ZAP70
Tyrosine-protein kinase ZAP-70

2

20

Small-scale

0.778

High

440054

LCK
Tyrosine-protein kinase Lck

2

20

Small-scale

0.737

High

849155

KSYK
Tyrosine-protein kinase SYK

2

20

Small-scale

0.737

High

463493

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.724

High

1094303

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.724

High

900303

FXR2
RNA-binding protein FXR2

5

1

High-throughput

0.718

High

1094312

LNX1
E3 ubiquitin-protein ligase LNX

2

4

High-throughput

0.700

High

651306

CBL
E3 ubiquitin-protein ligase CBL

4

6

Small-scale

0.683

High

711334

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.665

High

1094316

SH3G2
Endophilin-A1

1

20

High-throughput

0.656

High

410805

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

641585

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

1094302

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

1094314

STAM1
Signal transducing adapter molecule 1

1

16

Small-scale

0.647

High

1094306

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

20

High-throughput

0.621

High

440526

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.618

High

473410

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.618

High

557270

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

1060772

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.618

High

1063223

GOGA2
Golgin subfamily A member 2

3

4

High-throughput

0.616

High

1094319

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

Small-scale

0.614

High

990167

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.576

High

1048282

KPCT
Protein kinase C theta type

1

1

Small-scale

0.575

High

220371

LAT
Linker for activation of T-cells family member 1

2

1

Small-scale

0.571

High

1094308

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

5

Small-scale

0.569

High

1094301

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.536

High

437159

K2C8
Keratin, type II cytoskeletal 8

1

4

High-throughput

0.515

High

422024

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

971466

1433E
14-3-3 protein epsilon

1

5

Small-scale

0.501

High

1094313

HAVR2
Hepatitis A virus cellular receptor 2

1

0

Small-scale

0.481

High

385701

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

5

High-throughput

0.481

High

994505

YBOX1
Y-box-binding protein 1

1

1

High-throughput

0.481

High

637486

FLNA
Filamin-A

1

6

High-throughput

0.479

High

842646

WASP
Actin nucleation-promoting factor WAS

1

6

Small-scale

0.479

High

982071

RAP1A
Ras-related protein Rap-1A

1

9

Small-scale

0.479

High

1094305

AB1IP
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

1

6

Small-scale

0.479

High

1094307

SKAP1
Src kinase-associated phosphoprotein 1

1

13

Small-scale

0.479

High

1094310

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1094315

PRAM
PML-RARA-regulated adapter molecule 1

1

7

Small-scale

0.479

High

1094309

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1094311

PJA1
E3 ubiquitin-protein ligase Praja-1

1

2

Small-scale

0.457

High

1094317

WNK1
Serine/threonine-protein kinase WNK1

1

5

High-throughput

0.457

High

718391

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.457

High

1094320

ICOS
Inducible T-cell costimulator

1

0

Small-scale

0.426

High

553349

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

2

Small-scale

0.338

High

1094318

ELOV6
Very long chain fatty acid elongase 6

2

0

High-throughput

0.316

High

424399

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.269

Low

1094304

TRAT1
T-cell receptor-associated transmembrane adapter 1

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025