Protein: BLNK
B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)

Gene: BLNK
Organism: Homo sapiens
Interactions: 42
UniProt ID: Q8WV28

Gene Ontology (top 5):
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006954 - inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

987798

GRB2
Growth factor receptor-bound protein 2

7

20

Small-scale

0.964

High

1054128

BTK
Tyrosine-protein kinase BTK

6

20

Small-scale

0.937

High

849213

KSYK
Tyrosine-protein kinase SYK

3

20

Small-scale

0.827

High

410964

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

292857

GRAP2
GRB2-related adapter protein 2

2

20

Small-scale

0.768

High

1357683

CD2AP
CD2-associated protein

1

20

Small-scale

0.715

High

532092

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

599302

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

6

Small-scale

0.691

High

1357679

SH3K1
SH3 domain-containing kinase-binding protein 1

3

20

Small-scale

0.677

High

363625

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.647

High

641637

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

549838

CD79A
B-cell antigen receptor complex-associated protein alpha chain

3

0

Small-scale

0.639

High

222163

NCK2
Cytoplasmic protein NCK2

1

20

Small-scale

0.618

High

271281

CPNE3
Copine-3

1

1

High-throughput

0.618

High

463676

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.618

High

584570

VAV
Proto-oncogene vav

1

20

Small-scale

0.618

High

594058

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.618

High

619083

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

6

Small-scale

0.618

High

711166

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

10

Small-scale

0.618

High

855909

CRKL
Crk-like protein

1

20

Small-scale

0.618

High

1133323

MYPC3
Myosin-binding protein C, cardiac-type

1

16

Small-scale

0.618

High

1357680

VAV3
Guanine nucleotide exchange factor VAV3

1

20

Small-scale

0.618

High

651389

CBL
E3 ubiquitin-protein ligase CBL

1

13

Small-scale

0.561

High

1357678

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

11

Small-scale

0.561

High

520226

ANDR
Androgen receptor

1

18

High-throughput

0.536

High

1106494

GAB1
GRB2-associated-binding protein 1

1

19

High-throughput

0.536

High

853899

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

8

Small-scale

0.536

High

1272286

DOK3
Docking protein 3

1

18

Small-scale

0.536

High

1048935

REL
Proto-oncogene c-Rel

1

6

Small-scale

0.515

High

641468

CD72
B-cell differentiation antigen CD72

1

2

Small-scale

0.479

High

761783

HSP74
Heat shock 70 kDa protein 4

1

7

Small-scale

0.479

High

866766

CAZA2
F-actin-capping protein subunit alpha-2

1

1

Small-scale

0.479

High

867297

CAPZB
F-actin-capping protein subunit beta

1

1

Small-scale

0.479

High

898743

RL14
Large ribosomal subunit protein eL14

1

1

High-throughput

0.479

High

915142

CAZA1
F-actin-capping protein subunit alpha-1

1

1

Small-scale

0.479

High

1200922

WDR81
WD repeat-containing protein 81

1

4

Small-scale

0.479

High

1357677

HS105
Heat shock protein 105 kDa

1

8

Small-scale

0.479

High

1357681

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

1

1

Small-scale

0.479

High

1357682

TLN1
Talin-1

1

7

Small-scale

0.479

High

348628

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

Small-scale

0.458

High

1248459

SCIMP
SLP adapter and CSK-interacting membrane protein

1

1

Small-scale

0.445

High

1253999

CL17A
C-type lectin domain family 17, member A

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025