HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: ZFY21 (Q9BQ24)
Zinc finger FYVE domain-containing protein 21 (ZF21)
Gene: ZFYVE21

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28065597
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 234
+	Hs
		363495 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ZFY16_HUMAN (5-202): 1.59e-35: 135: 21.72
+	Hs
		336048 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ZFYV9_HUMAN (2-203): 1.78e-33: 129: 22.43
+	Hs
		169377 EGFR_HUMAN (1-1210): 0: 1246: 100.00		HGS_HUMAN (23-188): 1.52e-32: 126: 22.16
+	Hs
		363460 EGFR_HUMAN (1-1210): 0: 1246: 100.00		FGD5_HUMAN (1-169): 1.49e-29: 118: 17.06
+	Hs
		363961 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ANFY1_HUMAN (36-103): 7.67e-25: 104: 36.77
+	Hs
		169435 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		HGS_HUMAN (23-188): 1.52e-32: 126: 22.16
+	Hs
		169396 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		HGS_HUMAN (23-188): 1.52e-32: 126: 22.16
+	Hs
		710854 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		ZFY16_HUMAN (5-202): 1.59e-35: 135: 21.72
+	Hs
		932092 EPHA4_HUMAN (660-1016): 3.23e-121: 401: 31.52		ZFY16_HUMAN (5-202): 1.59e-35: 135: 21.72
+	Hs
		169450 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		HGS_HUMAN (23-188): 1.52e-32: 126: 22.16
+	Hs
		1147359 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		ZFY16_HUMAN (5-202): 1.59e-35: 135: 21.72
+	Hs
		336084 EPHA4_HUMAN (660-1016): 3.23e-121: 401: 31.52		ZFYV9_HUMAN (2-203): 1.78e-33: 129: 22.43
+	Hs
		169490 EPHA4_HUMAN (660-1016): 3.23e-121: 401: 31.52		HGS_HUMAN (23-188): 1.52e-32: 126: 22.16
+	Hs
		336106 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		ZFYV9_HUMAN (2-203): 1.78e-33: 129: 22.43
+	Hs
		169558 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		HGS_HUMAN (23-188): 1.52e-32: 126: 22.16
+	Hs
		169781 EPHA6_HUMAN (629-1016): 7.4e-119: 396: 27.80		HGS_HUMAN (23-188): 1.52e-32: 126: 22.16
+	Hs
		336071 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		ZFYV9_HUMAN (2-203): 1.78e-33: 129: 22.43
+	Hs
		169447 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		HGS_HUMAN (23-188): 1.52e-32: 126: 22.16
+	Hs
		465554 IGF1R_HUMAN (438-1062): 5.28e-109: 375: 20.53		FGD5_HUMAN (1-169): 1.49e-29: 118: 17.06
+	Hs
		710538 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		ANFY1_HUMAN (36-103): 7.67e-25: 104: 36.77