HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: EPHA6 (Q9UF33)
Ephrin type-A receptor 6 (EC 2.7.10.1) (EPH homology kinase 2) (EHK-2) (EPH-like kinase 12) (EK12)
Gene: EPHA6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 1036
+	Hs
		169558 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		EPHA7_HUMAN (15-1036): 0: 1206: 55.86
+	Hs
		169490 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		EPHA4_HUMAN (15-1036): 0: 1184: 56.88
+	Hs
		169489 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		EPHA5_HUMAN (11-1028): 0: 1183: 56.57
+	Hs
		169448 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		EPHA3_HUMAN (24-1028): 0: 1180: 59.88
+	Hs
		169450 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		EPHB2_HUMAN (34-1035): 0: 1165: 51.14
+	Hs
		169449 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		EPHA8_HUMAN (34-1036): 0: 1104: 52.54
+	Hs
		169447 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		EPHA2_HUMAN (31-1036): 0: 1054: 46.59
+	Hs
		931906 GGA3_HUMAN (6-678): 5.27e-48: 183: 13.96		EPHA5_HUMAN (11-1028): 0: 1183: 56.57
+	Hs
		710667 GGA3_HUMAN (6-678): 5.27e-48: 183: 13.96		EPHA3_HUMAN (24-1028): 0: 1180: 59.88
+	Hs
		710407 STAM1_HUMAN (4-172): 1.4e-42: 164: 28.40		EPHA2_HUMAN (31-1036): 0: 1054: 46.59
+	Hs
		169434 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		FGFR2_HUMAN (378-982): 1.28e-151: 472: 20.92
+	Hs
		169439 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		FGFR3_HUMAN (382-986): 1.52e-151: 472: 19.91
+	Hs
		169413 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		FGFR1_HUMAN (382-968): 4.18e-148: 463: 20.35
+	Hs
		169391 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		INSR_HUMAN (387-931): 6.39e-131: 432: 27.22
+	Hs
		641272 GGA3_HUMAN (6-678): 5.27e-48: 183: 13.96		FGFR2_HUMAN (378-982): 1.28e-151: 472: 20.92
+	Hs
		541721 GGA3_HUMAN (6-678): 5.27e-48: 183: 13.96		FGFR1_HUMAN (382-968): 4.18e-148: 463: 20.35
+	Hs
		641227 STAM1_HUMAN (4-172): 1.4e-42: 164: 28.40		FGFR2_HUMAN (378-982): 1.28e-151: 472: 20.92
+	Hs
		650332 STAM1_HUMAN (4-172): 1.4e-42: 164: 28.40		FGFR3_HUMAN (382-986): 1.52e-151: 472: 19.91
+	Hs
		541620 STAM1_HUMAN (4-172): 1.4e-42: 164: 28.40		FGFR1_HUMAN (382-968): 4.18e-148: 463: 20.35
+	Hs
		465671 GGA3_HUMAN (6-678): 5.27e-48: 183: 13.96		IGF1R_HUMAN (388-932): 6.13e-132: 434: 26.92