Protein: FGD5
FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23)

Gene: FGD5
Organism: Homo sapiens
Interactions: 212
UniProt ID: Q6ZNL6

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

964650

DCAF7
DDB1- and CUL4-associated factor 7

2

9

High-throughput

0.737

High

1014913

ARF1
ADP-ribosylation factor 1

2

7

High-throughput

0.737

High

651673

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

3

High-throughput

0.691

High

363460

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.681

High

981556

RAN
GTP-binding nuclear protein Ran

1

14

High-throughput

0.665

High

988466

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.647

High

465554

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.618

High

472084

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.618

High

992812

RACK1
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.618

High

1058867

ZO1
Tight junction protein 1

1

11

High-throughput

0.618

High

1091685

MYO1E
Unconventional myosin-Ie

1

20

High-throughput

0.618

High

1117392

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

High-throughput

0.618

High

1250723

MPRIP
Myosin phosphatase Rho-interacting protein

1

20

High-throughput

0.618

High

1253241

ZO2
Tight junction protein 2

1

11

High-throughput

0.618

High

1253253

MRCKB
Serine/threonine-protein kinase MRCK beta

1

8

High-throughput

0.618

High

1143171

PLEC
Plectin

2

20

High-throughput

0.601

High

1253231

PHB2
Prohibitin-2

2

3

High-throughput

0.601

High

942697

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

High-throughput

0.575

High

1253244

DBNL
Drebrin-like protein

2

19

High-throughput

0.571

High

216471

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.549

High

563959

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.541

High

1253245

AKA11
A-kinase anchor protein 11

1

1

High-throughput

0.536

High

669926

MCM3
DNA replication licensing factor MCM3

2

9

High-throughput

0.521

High

1097372

CBX3
Chromobox protein homolog 3

2

3

High-throughput

0.521

High

972460

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.515

High

280677

PR40A
Pre-mRNA-processing factor 40 homolog A

1

11

High-throughput

0.515

High

562159

LAMP2
Lysosome-associated membrane glycoprotein 2

1

8

High-throughput

0.515

High

1239612

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

1

High-throughput

0.508

High

937043

CASP6
Caspase-6

1

0

High-throughput

0.493

High

123744

MYO1C
Unconventional myosin-Ic

1

19

High-throughput

0.479

High

128001

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

High-throughput

0.479

High

158239

COPE
Coatomer subunit epsilon

1

4

High-throughput

0.479

High

171265

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

9

High-throughput

0.479

High

179364

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

High-throughput

0.479

High

224734

ACTN4
Alpha-actinin-4

1

14

High-throughput

0.479

High

227910

MYO1B
Unconventional myosin-Ib

1

20

High-throughput

0.479

High

278114

FLNB
Filamin-B

1

20

High-throughput

0.479

High

299251

FLOT1
Flotillin-1

1

13

High-throughput

0.479

High

336448

SVIL
Supervillin

1

11

High-throughput

0.479

High

343971

HS74L
Heat shock 70 kDa protein 4L

1

10

High-throughput

0.479

High

345979

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

358719

LDHA
L-lactate dehydrogenase A chain

1

5

High-throughput

0.479

High

385132

K1C14
Keratin, type I cytoskeletal 14

1

7

High-throughput

0.479

High

385289

K2C6A
Keratin, type II cytoskeletal 6A

1

7

High-throughput

0.479

High

402617

ALDOA
Fructose-bisphosphate aldolase A

1

1

High-throughput

0.479

High

404147

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

407308

K2C6B
Keratin, type II cytoskeletal 6B

1

7

High-throughput

0.479

High

407476

K2C1
Keratin, type II cytoskeletal 1

1

6

High-throughput

0.479

High

426289

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

1

High-throughput

0.479

High

436909

K1C18
Keratin, type I cytoskeletal 18

1

7

High-throughput

0.479

High

437231

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.479

High

442373

GELS
Gelsolin

1

11

High-throughput

0.479

High

443848

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

4

High-throughput

0.479

High

445929

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

451010

LDHB
L-lactate dehydrogenase B chain

1

5

High-throughput

0.479

High

452304

PDIA1
Protein disulfide-isomerase

1

7

High-throughput

0.479

High

456769

ANXA2
Annexin A2

1

2

High-throughput

0.479

High

457511

TBB5
Tubulin beta chain

1

8

High-throughput

0.479

High

461619

HS90A
Heat shock protein HSP 90-alpha

1

4

High-throughput

0.479

High

464277

FUMH
Fumarate hydratase, mitochondrial

1

1

High-throughput

0.479

High

468520

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

475767

K2C7
Keratin, type II cytoskeletal 7

1

5

High-throughput

0.479

High

476343

K1C16
Keratin, type I cytoskeletal 16

1

7

High-throughput

0.479

High

476733

RSSA
Small ribosomal subunit protein uS2

1

1

High-throughput

0.479

High

479148

ENOG
Gamma-enolase

1

2

High-throughput

0.479

High

532696

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

535219

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

537376

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

550335

PABP1
Polyadenylate-binding protein 1

1

8

High-throughput

0.479

High

552617

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

553359

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

1

High-throughput

0.479

High

555708

ACTN1
Alpha-actinin-1

1

14

High-throughput

0.479

High

558216

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

566172

K1C10
Keratin, type I cytoskeletal 10

1

8

High-throughput

0.479

High

566406

K2C5
Keratin, type II cytoskeletal 5

1

6

High-throughput

0.479

High

566723

PDIA4
Protein disulfide-isomerase A4

1

7

High-throughput

0.479

High

571458

GLU2B
Glucosidase 2 subunit beta

1

2

High-throughput

0.479

High

573142

KPYM
Pyruvate kinase PKM

1

1

High-throughput

0.479

High

573965

MYL6B
Myosin light chain 6B

1

6

High-throughput

0.479

High

576784

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

586757

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

610730

TCPA
T-complex protein 1 subunit alpha

1

4

High-throughput

0.479

High

612682

RL7
Large ribosomal subunit protein uL30

1

2

High-throughput

0.479

High

618705

ML12A
Myosin regulatory light chain 12A

1

6

High-throughput

0.479

High

620429

NUCL
Nucleolin

1

7

High-throughput

0.479

High

637586

FLNA
Filamin-A

1

20

High-throughput

0.479

High

658245

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

659794

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.479

High

666316

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

2

High-throughput

0.479

High

666759

MYL9
Myosin regulatory light polypeptide 9

1

6

High-throughput

0.479

High

680404

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

4

High-throughput

0.479

High

688042

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.479

High

691152

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

698309

MAP4
Microtubule-associated protein 4

1

6

High-throughput

0.479

High

712225

TKT
Transketolase

1

1

High-throughput

0.479

High

732341

PRDX2
Peroxiredoxin-2

1

7

High-throughput

0.479

High

749941

KINH
Kinesin-1 heavy chain

1

5

High-throughput

0.479

High

761728

HSP74
Heat shock 70 kDa protein 4

1

10

High-throughput

0.479

High

772019

K1C9
Keratin, type I cytoskeletal 9

1

7

High-throughput

0.479

High

772869

MYH9
Myosin-9

1

12

High-throughput

0.479

High

773209

MYH10
Myosin-10

1

12

High-throughput

0.479

High

776827

MYH11
Myosin-11

1

12

High-throughput

0.479

High

777499

K22E
Keratin, type II cytoskeletal 2 epidermal

1

7

High-throughput

0.479

High

801381

HSPA9
Stress-70 protein, mitochondrial

1

6

High-throughput

0.479

High

821419

TCPZ
T-complex protein 1 subunit zeta

1

4

High-throughput

0.479

High

828819

MDHM
Malate dehydrogenase, mitochondrial

1

5

High-throughput

0.479

High

834474

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

841800

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

862667

UTRN
Utrophin

1

20

High-throughput

0.479

High

862884

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

9

High-throughput

0.479

High

867226

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

876031

TCPE
T-complex protein 1 subunit epsilon

1

6

High-throughput

0.479

High

881215

FAS
Fatty acid synthase

1

1

High-throughput

0.479

High

881994

TCPG
T-complex protein 1 subunit gamma

1

6

High-throughput

0.479

High

899098

TCPQ
T-complex protein 1 subunit theta

1

7

High-throughput

0.479

High

899445

TCPD
T-complex protein 1 subunit delta

1

5

High-throughput

0.479

High

906424

DHB4
Peroxisomal multifunctional enzyme type 2

1

2

High-throughput

0.479

High

906547

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

5

High-throughput

0.479

High

910955

IMA1
Importin subunit alpha-1

1

4

High-throughput

0.479

High

920832

ACLY
ATP-citrate synthase

1

3

High-throughput

0.479

High

934770

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

935899

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

2

High-throughput

0.479

High

939360

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

4

High-throughput

0.479

High

952585

MYL6
Myosin light polypeptide 6

1

6

High-throughput

0.479

High

952912

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.479

High

959834

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.479

High

967814

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

20

High-throughput

0.479

High

968354

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

20

High-throughput

0.479

High

971677

1433E
14-3-3 protein epsilon

1

6

High-throughput

0.479

High

975765

RL7A
Large ribosomal subunit protein eL8

1

2

High-throughput

0.479

High

977280

RS4X
Small ribosomal subunit protein eS4, X isoform

1

3

High-throughput

0.479

High

989023

AP2B1
AP-2 complex subunit beta

1

12

High-throughput

0.479

High

994613

YBOX1
Y-box-binding protein 1

1

3

High-throughput

0.479

High

995432

TPM4
Tropomyosin alpha-4 chain

1

5

High-throughput

0.479

High

995655

ACTC
Actin, alpha cardiac muscle 1

1

10

High-throughput

0.479

High

996214

EF1A1
Elongation factor 1-alpha 1

1

3

High-throughput

0.479

High

996484

ACTS
Actin, alpha skeletal muscle

1

10

High-throughput

0.479

High

996738

TBA1B
Tubulin alpha-1B chain

1

9

High-throughput

0.479

High

997392

TBB4B
Tubulin beta-4B chain

1

8

High-throughput

0.479

High

1005895

GTF2I
General transcription factor II-I

1

1

High-throughput

0.479

High

1007098

TCPB
T-complex protein 1 subunit beta

1

6

High-throughput

0.479

High

1026097

CLH1
Clathrin heavy chain 1

1

4

High-throughput

0.479

High

1039260

RL6
Large ribosomal subunit protein eL6

1

1

High-throughput

0.479

High

1040320

DYST
Dystonin

1

20

High-throughput

0.479

High

1047032

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

5

High-throughput

0.479

High

1047435

K1C17
Keratin, type I cytoskeletal 17

1

7

High-throughput

0.479

High

1051778

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.479

High

1052049

CALD1
Caldesmon

1

20

High-throughput

0.479

High

1068243

AHNK
Neuroblast differentiation-associated protein AHNAK

1

6

High-throughput

0.479

High

1092570

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

5

High-throughput

0.479

High

1093255

FLII
Protein flightless-1 homolog

1

14

High-throughput

0.479

High

1098041

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

High-throughput

0.479

High

1118504

TBB2A
Tubulin beta-2A chain

1

8

High-throughput

0.479

High

1123946

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

4

High-throughput

0.479

High

1125352

FLNC
Filamin-C

1

20

High-throughput

0.479

High

1136543

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.479

High

1136974

SEPT2
Septin-2

1

6

High-throughput

0.479

High

1143953

IPYR
Inorganic pyrophosphatase

1

1

High-throughput

0.479

High

1156381

SEPT7
Septin-7

1

6

High-throughput

0.479

High

1157775

DDB1
DNA damage-binding protein 1

1

4

High-throughput

0.479

High

1158668

DPYL2
Dihydropyrimidinase-related protein 2

1

7

High-throughput

0.479

High

1160667

DREB
Drebrin

1

8

High-throughput

0.479

High

1199793

AGK
Acylglycerol kinase, mitochondrial

1

2

High-throughput

0.479

High

1229818

CYTSA
Cytospin-A

1

20

High-throughput

0.479

High

1253222

TBA1A
Tubulin alpha-1A chain

1

9

High-throughput

0.479

High

1253223

MYH14
Myosin-14

1

12

High-throughput

0.479

High

1253224

LUZP1
Leucine zipper protein 1

1

20

High-throughput

0.479

High

1253226

LMO7
LIM domain only protein 7

1

9

High-throughput

0.479

High

1253227

MY18A
Unconventional myosin-XVIIIa

1

19

High-throughput

0.479

High

1253229

DOCK7
Dedicator of cytokinesis protein 7

1

5

High-throughput

0.479

High

1253230

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

3

High-throughput

0.479

High

1253232

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.479

High

1253233

TCPH
T-complex protein 1 subunit eta

1

6

High-throughput

0.479

High

1253234

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1253236

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

20

High-throughput

0.479

High

1253238

TMOD3
Tropomodulin-3

1

11

High-throughput

0.479

High

1253239

RAI14
Ankycorbin

1

20

High-throughput

0.479

High

1253240

RRBP1
Ribosome-binding protein 1

1

19

High-throughput

0.479

High

1253242

LIMA1
LIM domain and actin-binding protein 1

1

10

High-throughput

0.479

High

1253243

SEPT9
Septin-9

1

6

High-throughput

0.479

High

1253246

MYO6
Unconventional myosin-VI

1

17

High-throughput

0.479

High

1253247

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

2

High-throughput

0.479

High

1253248

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

20

High-throughput

0.479

High

1253249

LIMC1
LIM and calponin homology domains-containing protein 1

1

6

High-throughput

0.479

High

1253250

RTRAF
RNA transcription, translation and transport factor protein

1

2

High-throughput

0.479

High

1253251

PLAK2
PALM2-AKAP2 fusion protein

1

3

High-throughput

0.479

High

1253252

TRRAP
Transformation/transcription domain-associated protein

1

6

High-throughput

0.479

High

1253256

MYH4
Myosin-4

1

9

High-throughput

0.479

High

362050

AATM
Aspartate aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

390080

ALBU
Albumin

1

0

High-throughput

0.458

High

408948

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

646866

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

714897

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.458

High

861490

GNPI1
Glucosamine-6-phosphate deaminase 1

1

0

High-throughput

0.458

High

949169

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

1032492

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

High-throughput

0.458

High

1253228

PAWR
PRKC apoptosis WT1 regulator protein

1

0

High-throughput

0.458

High

1253235

TMM43
Transmembrane protein 43

1

0

High-throughput

0.458

High

1253255

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.458

High

1253221

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.445

High

106142

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

553835

KCRU
Creatine kinase U-type, mitochondrial

1

1

High-throughput

0.437

High

568439

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

829437

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.437

High

882739

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.437

High

999534

NOMO3
BOS complex subunit NOMO3

1

2

High-throughput

0.437

High

1143628

NOMO1
BOS complex subunit NOMO1

1

2

High-throughput

0.437

High

1253237

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

1

High-throughput

0.437

High

1253254

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

20

High-throughput

0.437

High

724114

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

3

0

High-throughput

0.330

High

1253225

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.268

Low

551113

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025