HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CADM1 (Q9BY67)
Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
Gene: CADM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	39499777
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Furin-like~V-set, GF_recep_IV~V-set, Recep_L_domain~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0016323 - basolateral plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 442
+	Hs
		363899 EGFR_HUMAN (1-1210): 0: 1246: 100.00		NECT3_HUMAN (52-439): 4.92e-73: 240: 23.25
+	Hs
		363493 EGFR_HUMAN (1-1210): 0: 1246: 100.00		NEGR1_HUMAN (1-349): 5.06e-64: 212: 20.06
+	Hs
		411034 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		CADM1_HUMAN (1-442): 6.86e-84: 265: 100.00
+	Hs
		411070 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		NECT3_HUMAN (52-439): 4.92e-73: 240: 23.25
+	Hs
		363152 EGFR_HUMAN (1-1210): 0: 1246: 100.00		CNTN2_HUMAN (34-235): 3.26e-19: 92.7: 13.17
+	Hs
		363714 EGFR_HUMAN (1-1210): 0: 1246: 100.00		KIRR1_HUMAN (19-245): 2.92e-18: 89.6: 14.59
+	Hs
		410853 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		OPCM_HUMAN (29-329): 1.95e-65: 215: 23.40
+	Hs
		410919 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		NEGR1_HUMAN (1-349): 5.06e-64: 212: 20.06
+	Hs
		363659 EGFR_HUMAN (1-1210): 0: 1246: 100.00		NECT2_HUMAN (109-334): 8.36e-15: 78.2: 27.07
+	Hs
		363641 EGFR_HUMAN (1-1210): 0: 1246: 100.00		TITIN_HUMAN (122-441): 6.65e-09: 60.7: 12.97
+	Hs
		411001 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		KIRR1_HUMAN (19-245): 2.92e-18: 89.6: 14.59
+	Hs
		410976 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		NECT2_HUMAN (109-334): 8.36e-15: 78.2: 27.07
+	Hs
		710375 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		CADM4_HUMAN (45-442): 2.65e-74: 239: 35.18
+	Hs
		710247 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		OPCM_HUMAN (29-329): 1.95e-65: 215: 23.40
+	Hs
		710503 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		ROBO2_HUMAN (138-438): 5.1e-51: 187: 16.08
+	Hs
		710600 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		ROBO1_HUMAN (18-378): 8.48e-33: 133: 14.61
+	Hs
		1147408 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		KIRR1_HUMAN (19-245): 2.92e-18: 89.6: 14.59
+	Hs
		580772 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		PVR_HUMAN (95-336): 1.06e-14: 77.4: 28.35
+	Hs
		710428 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		KIRR1_HUMAN (19-245): 2.92e-18: 89.6: 14.59
+	Hs
		710404 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		NECT2_HUMAN (109-334): 8.36e-15: 78.2: 27.07