HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: NECT2 (Q92692)
Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)
Gene: NECTIN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	39499777
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Furin-like~V-set, GF_recep_IV~V-set, Recep_L_domain~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0015026 - coreceptor activity GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 538
+	Hs
		411034 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		CADM1_HUMAN (40-348): 8.18e-67: 224: 20.25
+	Hs
		410853 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		OPCM_HUMAN (20-372): 1.58e-59: 202: 15.99
+	Hs
		411070 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		NECT3_HUMAN (30-510): 3.44e-52: 188: 20.54
+	Hs
		411002 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		LRIG1_HUMAN (153-427): 3.13e-33: 137: 14.14
+	Hs
		411001 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		KIRR1_HUMAN (33-363): 7.42e-16: 82.9: 16.72
+	Hs
		363659 EGFR_HUMAN (16-1253): 0: 1078: 48.80		NECT2_HUMAN (1-538): 2.84e-91: 291: 100.00
+	Hs
		410811 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		PTK7_HUMAN (263-483): 1.84e-13: 75.5: 15.45
+	Hs
		363819 EGFR_HUMAN (16-1253): 0: 1078: 48.80		CADM1_HUMAN (40-348): 8.18e-67: 224: 20.25
+	Hs
		363899 EGFR_HUMAN (16-1253): 0: 1078: 48.80		NECT3_HUMAN (30-510): 3.44e-52: 188: 20.54
+	Hs
		1145766 ERBB4_HUMAN (6-1232): 0: 1103: 45.86		LRIG1_HUMAN (153-427): 3.13e-33: 137: 14.14
+	Mm
		999820 EGFR_MOUSE (17-1254): 0: 1135: 48.72		LRIG1_MOUSE (259-527): 8.1e-19: 92.5: 14.98
+	Hs
		363715 EGFR_HUMAN (16-1253): 0: 1078: 48.80		LRIG1_HUMAN (153-427): 3.13e-33: 137: 14.14
+	Hs
		320853 EGFR_HUMAN (16-1253): 0: 1078: 48.80		LRIG2_HUMAN (161-392): 1.55e-32: 135: 16.19
+	Hs
		641652 ERBB3_HUMAN (5-1252): 0: 1047: 38.79		LRIG1_HUMAN (153-427): 3.13e-33: 137: 14.14
+	Hs
		363714 EGFR_HUMAN (16-1253): 0: 1078: 48.80		KIRR1_HUMAN (33-363): 7.42e-16: 82.9: 16.72
+	Hs
		363641 EGFR_HUMAN (16-1253): 0: 1078: 48.80		TITIN_HUMAN (171-460): 8.42e-09: 60.9: 13.68
+	Hs
		464032 RET_HUMAN (426-1088): 1.34e-129: 428: 23.46		LRIG1_HUMAN (153-427): 3.13e-33: 137: 14.14
+	Hs
		320856 RET_HUMAN (426-1088): 1.34e-129: 428: 23.46		LRIG2_HUMAN (161-392): 1.55e-32: 135: 16.19
+	Mm
		772091 RET_MOUSE (426-1088): 3.78e-124: 413: 22.78		LRIG1_MOUSE (259-527): 8.1e-19: 92.5: 14.98
+	Hs
		463952 RET_HUMAN (426-1088): 1.34e-129: 428: 23.46		PTK7_HUMAN (263-483): 1.84e-13: 75.5: 15.45