HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: NECT2 (Q92692)
Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)
Gene: NECTIN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ephrin_lbd~V-set, V-set~fn3
Common GO terms	GO:0001618 - virus receptor activity GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 538
+	Hs
		710247 EPHA2_HUMAN (1-976): 0: 1124: 100.00		OPCM_HUMAN (20-372): 1.58e-59: 202: 15.99
+	Hs
		580772 EPHA7_HUMAN (4-974): 0: 1120: 50.15		PVR_HUMAN (25-423): 4.78e-59: 203: 43.92
+	Hs
		710600 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ROBO1_HUMAN (37-532): 4.85e-54: 199: 12.60
+	Hs
		710428 EPHA2_HUMAN (1-976): 0: 1124: 100.00		KIRR1_HUMAN (33-363): 7.42e-16: 82.9: 16.72
+	Hs
		1147408 EPHA7_HUMAN (4-974): 0: 1120: 50.15		KIRR1_HUMAN (33-363): 7.42e-16: 82.9: 16.72
+	Hs
		710220 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PTK7_HUMAN (263-483): 1.84e-13: 75.5: 15.45
+	Hs
		710375 EPHA2_HUMAN (1-976): 0: 1124: 100.00		CADM4_HUMAN (267-538): 2.28e-12: 70.9: 11.38
+	Hs
		710503 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ROBO2_HUMAN (449-538): 3.83e-09: 61.7: 15.15
+	Hs
		580729 EPHA1_HUMAN (17-967): 0: 947: 49.28		PVR_HUMAN (25-423): 4.78e-59: 203: 43.92
+	Hs
		640241 EPHA1_HUMAN (17-967): 0: 947: 49.28		TITIN_HUMAN (171-460): 8.42e-09: 60.9: 13.68
+	Hs
		181805 EPHB6_HUMAN (28-962): 0: 869: 37.40		CADM4_HUMAN (267-538): 2.28e-12: 70.9: 11.38
+	Ce
		109605 VAB1_CAEEL (3-953): 0: 749: 29.00		SAX3_CAEEL (33-445): 2.24e-49: 185: 13.51
+	Hs
		650170 FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65		NECT1_HUMAN (19-466): 7.36e-57: 200: 28.66
+	Hs
		249127 MERTK_HUMAN (270-900): 1e-144: 458: 23.90		DSCAM_HUMAN (43-532): 1.85e-14: 79: 9.38
+	Hs
		439722 INSR_HUMAN (281-911): 2.91e-136: 444: 24.78		PTK7_HUMAN (263-483): 1.84e-13: 75.5: 15.45
+	Hs
		463688 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		NECT2_HUMAN (1-538): 2.84e-91: 291: 100.00
+	Hs
		465508 IGF1R_HUMAN (393-877): 1.45e-133: 437: 29.90		PTK7_HUMAN (263-483): 1.84e-13: 75.5: 15.45
+	Hs
		463707 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		KIRR1_HUMAN (33-363): 7.42e-16: 82.9: 16.72
+	Hs
		463499 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		PTK7_HUMAN (263-483): 1.84e-13: 75.5: 15.45
+	Hs
		463779 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		ROBO2_HUMAN (449-538): 3.83e-09: 61.7: 15.15