HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: BI2L1 (Q9UHR4)
BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)
Gene: BAIAP2L1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 511
+	Hs
		364042 EGFR_HUMAN (1-1210): 0: 1246: 100.00		BAIP2_HUMAN (6-505): 1.43e-118: 361: 39.55
+	Hs
		364024 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PACN2_HUMAN (8-401): 3.85e-86: 275: 13.07
+	Hs
		363335 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ITSN1_HUMAN (6-491): 1.89e-27: 119: 11.80
+	Hs
		363943 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ITSN2_HUMAN (225-399): 4.89e-10: 64.6: 14.29
+	Hs
		710913 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		BI2L1_HUMAN (1-511): 8.26e-169: 488: 100.00
+	Hs
		932150 EPHA4_HUMAN (660-1016): 3.23e-121: 401: 31.52		BI2L1_HUMAN (1-511): 8.26e-169: 488: 100.00
+	Hs
		1147458 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		BI2L1_HUMAN (1-511): 8.26e-169: 488: 100.00
+	Hs
		710552 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		BI2L1_HUMAN (1-511): 8.26e-169: 488: 100.00
+	Hs
		464082 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		BAIP2_HUMAN (6-505): 1.43e-118: 361: 39.55
+	Hs
		710918 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		BAIP2_HUMAN (6-505): 1.43e-118: 361: 39.55
+	Hs
		932156 EPHA4_HUMAN (660-1016): 3.23e-121: 401: 31.52		BAIP2_HUMAN (6-505): 1.43e-118: 361: 39.55
+	Hs
		1147466 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		BAIP2_HUMAN (6-505): 1.43e-118: 361: 39.55
+	Hs
		710917 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		PACN2_HUMAN (8-401): 3.85e-86: 275: 13.07
+	Hs
		932155 EPHA4_HUMAN (660-1016): 3.23e-121: 401: 31.52		PACN2_HUMAN (8-401): 3.85e-86: 275: 13.07
+	Hs
		1147464 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		PACN2_HUMAN (8-401): 3.85e-86: 275: 13.07
+	Mm
		362441 ABL1_MOUSE (704-1180): 8.92e-119: 397: 26.84		PPIP1_MOUSE (10-400): 9.17e-65: 217: 13.82
+	Hs
		1147356 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		MTSS2_HUMAN (18-334): 2.75e-53: 194: 14.37
+	Hs
		710326 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		MTSS2_HUMAN (18-334): 2.75e-53: 194: 14.37
+	Hs
		710840 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		ITSN1_HUMAN (6-491): 1.89e-27: 119: 11.80
+	Hs
		710527 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		ITSN2_HUMAN (225-399): 4.89e-10: 64.6: 14.29