HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RhoGEF~fn3, PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 1697
+	Hs
		710840 EPHB2_HUMAN (28-973): 0: 1077: 48.29		ITSN1_HUMAN (2-1693): 0: 828: 56.00
+	Hs
		710106 EPHA2_HUMAN (1-976): 0: 1124: 100.00		EPS15_HUMAN (7-420): 8.38e-32: 137: 14.73
+	Hs
		710295 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ARHGG_HUMAN (1196-1469): 3.2e-21: 102: 30.27
+	Mm
		1041407 EPHA4_MOUSE (1-974): 0: 1113: 50.56		NGEF_MOUSE (1200-1461): 1.5e-19: 97.4: 28.94
+	Hs
		299518 EPHA2_HUMAN (1-976): 0: 1124: 100.00		TRIO_HUMAN (178-881): 2.4e-11: 71.4: 8.54
+	Hs
		299548 EPHA7_HUMAN (4-974): 0: 1120: 50.15		TRIO_HUMAN (178-881): 2.4e-11: 71.4: 8.54
+	Hs
		913632 EPHA4_HUMAN (1-974): 0: 1110: 50.35		VAV2_HUMAN (584-1183): 8.14e-12: 72.6: 11.00
+	Hs
		463538 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		ITSN1_HUMAN (2-1693): 0: 828: 56.00
+	Hs
		720348 UFO_HUMAN (294-911): 1.96e-144: 454: 24.15		EP15R_HUMAN (11-510): 1.51e-36: 152: 16.77
+	Hs
		584528 MERTK_HUMAN (270-900): 1e-144: 458: 23.90		VAV_HUMAN (255-1041): 6.16e-24: 111: 12.88
+	Hs
		439632 INSR_HUMAN (281-911): 2.91e-136: 444: 24.78		VAV_HUMAN (255-1041): 6.16e-24: 111: 12.88
+	Rn
		108178 INSR_RAT (371-873): 1.87e-134: 440: 29.49		G3V856_RAT (1200-1461): 1.08e-21: 103: 30.04
+	Hs
		439876 INSR_HUMAN (281-911): 2.91e-136: 444: 24.78		VAV3_HUMAN (255-1038): 3.63e-19: 96.5: 13.46
+	Hs
		465672 IGF1R_HUMAN (393-877): 1.45e-133: 437: 29.90		ARHGC_HUMAN (1189-1535): 2.95e-21: 103: 27.07
+	Hs
		465690 IGF1R_HUMAN (393-877): 1.45e-133: 437: 29.90		VAV3_HUMAN (255-1038): 3.63e-19: 96.5: 13.46
+	Hs
		299507 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		TRIO_HUMAN (178-881): 2.4e-11: 71.4: 8.54
+	Hs
		463564 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		SH319_HUMAN (1035-1211): 6.57e-11: 69.3: 28.26