HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.884

Property	Details
Experiments	25402006, 24658140, 35384245, unassigned2173
Identification Methods	two hybrid, protein complementation assay, proximity labelling technology, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0097708 - intracellular vesicle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1697
+	Hs
		363335 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ITSN1_HUMAN (2-1693): 0: 828: 56.00
+	Hs
		238818 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		KALRN_HUMAN (215-1602): 4.23e-87: 319: 12.20
+	Mm
		839854 EGFR_MOUSE (1-1210): 0: 1267: 90.35		EPS15_MOUSE (7-405): 1.37e-31: 136: 17.60
+	Hs
		362920 EGFR_HUMAN (1-1210): 0: 1246: 100.00		EPS15_HUMAN (7-420): 8.38e-32: 137: 14.73
+	Mm
		699350 EGFR_MOUSE (1-1210): 0: 1267: 90.35		VAV_MOUSE (255-1041): 6.95e-24: 111: 12.62
+	Hs
		362701 EGFR_HUMAN (1-1210): 0: 1246: 100.00		VAV_HUMAN (255-1041): 6.16e-24: 111: 12.88
+	Hs
		363696 EGFR_HUMAN (1-1210): 0: 1246: 100.00		Q96D37_HUMAN (273-1041): 9.17e-24: 111: 12.49
+	Hs
		363944 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ARHGC_HUMAN (1189-1535): 2.95e-21: 103: 27.07
+	Hs
		364011 EGFR_HUMAN (1-1210): 0: 1246: 100.00		VAV3_HUMAN (255-1038): 3.63e-19: 96.5: 13.46
+	Hs
		363013 EGFR_HUMAN (1-1210): 0: 1246: 100.00		VAV2_HUMAN (584-1183): 8.14e-12: 72.6: 11.00
+	Hs
		363387 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SH319_HUMAN (1035-1211): 6.57e-11: 69.3: 28.26
+	Hs
		363274 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ARHG7_HUMAN (855-1001): 2.75e-10: 67.6: 20.27
+	Hs
		584544 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		VAV_HUMAN (255-1041): 6.16e-24: 111: 12.88
+	Hs
		410687 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		EPS15_HUMAN (7-420): 8.38e-32: 137: 14.73
+	Hs
		1145793 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		VAV3_HUMAN (255-1038): 3.63e-19: 96.5: 13.46
+	Hs
		410582 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		VAV_HUMAN (255-1041): 6.16e-24: 111: 12.88
+	Hs
		410995 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		Q96D37_HUMAN (273-1041): 9.17e-24: 111: 12.49
+	Hs
		913652 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		VAV2_HUMAN (584-1183): 8.14e-12: 72.6: 11.00
+	Hs
		411109 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		VAV3_HUMAN (255-1038): 3.63e-19: 96.5: 13.46
+	Hs
		410727 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		VAV2_HUMAN (584-1183): 8.14e-12: 72.6: 11.00