HitPredict

Interactor 1: CXCL7 (P02775)
Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))]
Gene: PPBP

Interactor 2: CXCR2 (P25025)
C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182)
Gene: CXCR2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	8550564, 8702798, 9126332
Identification Methods	experimental interaction detection, biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006954 - inflammatory response GO:0030593 - neutrophil chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 360
+	Hs
		625748 CXCL5_HUMAN (49-128): 2.33e-28: 101: 45.00		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		587767 CXCL2_HUMAN (51-127): 1.75e-27: 99.4: 50.65		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		364041 CXCL7_HUMAN (1-128): 2.12e-41: 135: 100.00		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		587786 CXCL3_HUMAN (57-127): 1.67e-26: 96.7: 50.70		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		625758 CXCL6_HUMAN (50-128): 2.91e-26: 96.3: 40.51		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		448988 GROA_HUMAN (57-127): 3.17e-26: 95.9: 57.75		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		486185 IL8_HUMAN (50-127): 6.11e-25: 92.5: 43.04		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Mm
		500672 CXCL2_MOUSE (51-127): 2.03e-29: 104: 49.35		CXCR2_MOUSE (1-348): 2e-78: 246: 70.69
+	Mm
		522397 GROA_MOUSE (53-123): 1.4e-27: 99: 59.16		CXCR2_MOUSE (1-348): 2e-78: 246: 70.69
+	Hs
		217751 CXL13_HUMAN (51-127): 5.3e-24: 90.6: 24.36		CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71
+	Hs
		364080 PLF4_HUMAN (51-123): 5.15e-23: 87.9: 50.69		CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71
+	Hs
		830623 CXCL9_HUMAN (53-119): 1.2e-18: 77.5: 33.82		CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71
+	Hs
		625736 CXCL5_HUMAN (49-128): 2.33e-28: 101: 45.00		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		625737 CXCL6_HUMAN (50-128): 2.91e-26: 96.3: 40.51		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		448987 GROA_HUMAN (57-127): 3.17e-26: 95.9: 57.75		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		486184 IL8_HUMAN (50-127): 6.11e-25: 92.5: 43.04		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		217747 CXL13_HUMAN (51-127): 5.3e-24: 90.6: 24.36		CXCR5_HUMAN (3-360): 2.25e-65: 213: 35.42
+	Hs
		217753 CXL13_HUMAN (51-127): 5.3e-24: 90.6: 24.36		ACKR4_HUMAN (4-358): 2.16e-65: 212: 31.55
+	Mm
		291524 CXL10_MOUSE (48-126): 3.81e-21: 82.8: 28.40		CXCR3_MOUSE (21-325): 9.97e-63: 206: 42.67
+	Mm
		291525 CXCL9_MOUSE (54-119): 4.78e-20: 80.9: 38.81		CXCR3_MOUSE (21-325): 9.97e-63: 206: 42.67