HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: BRD8 (Q9H0E9)
Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120)
Gene: BRD8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 1235
+	Hs
		370719 ESR1_HUMAN (1-595): 0: 599: 100.00		TRI33_HUMAN (820-1232): 7.65e-33: 140: 11.56
+	Hs
		170202 ESR1_HUMAN (1-595): 0: 599: 100.00		TIF1A_HUMAN (845-1228): 4.33e-31: 134: 14.07
+	Hs
		370655 ESR1_HUMAN (1-595): 0: 599: 100.00		BAZ2A_HUMAN (125-815): 2.72e-30: 132: 10.85
+	Hs
		370499 ESR1_HUMAN (1-595): 0: 599: 100.00		BRD7_HUMAN (1005-1212): 3.07e-29: 127: 15.02
+	Hs
		369484 ESR1_HUMAN (1-595): 0: 599: 100.00		EP300_HUMAN (807-1211): 2.38e-27: 123: 13.66
+	Mm
		587105 ESR1_MOUSE (1-595): 0: 570: 88.98		TIF1A_MOUSE (845-1224): 6.54e-32: 137: 13.97
+	Hs
		369920 ESR1_HUMAN (1-595): 0: 599: 100.00		PB1_HUMAN (987-1226): 1.89e-22: 107: 15.45
+	Mm
		70893 ESR1_MOUSE (1-595): 0: 570: 88.98		EP300_MOUSE (807-1211): 8.19e-30: 131: 15.12
+	Hs
		369975 ESR1_HUMAN (1-595): 0: 599: 100.00		TAF1L_HUMAN (1101-1206): 4.22e-19: 96.3: 21.70
+	Hs
		369214 ESR1_HUMAN (1-595): 0: 599: 100.00		SMCA4_HUMAN (1057-1208): 7.26e-19: 95.5: 13.84
+	Hs
		370140 ESR1_HUMAN (1-595): 0: 599: 100.00		KAT2A_HUMAN (684-810): 1.1e-12: 74.9: 17.32
+	Hs
		370136 ESR1_HUMAN (1-595): 0: 599: 100.00		CBP_HUMAN (125-595): 9.03e-09: 62.2: 12.22
+	Mm
		101423 ESR1_MOUSE (1-595): 0: 570: 88.98		F8VPR5_MOUSE (105-556): 1.4e-10: 68.4: 9.87
+	Hs
		1017331 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		BPTF_HUMAN (130-1222): 5.45e-42: 171: 9.55
+	Hs
		170435 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TIF1A_HUMAN (845-1228): 4.33e-31: 134: 14.07
+	Hs
		998934 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		EP300_HUMAN (807-1211): 2.38e-27: 123: 13.66
+	Hs
		1199171 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PB1_HUMAN (987-1226): 1.89e-22: 107: 15.45
+	Hs
		847036 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMCA4_HUMAN (1057-1208): 7.26e-19: 95.5: 13.84
+	Hs
		1269279 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		KAT2A_HUMAN (684-810): 1.1e-12: 74.9: 17.32
+	Hs
		1269276 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CBP_HUMAN (125-595): 9.03e-09: 62.2: 12.22