Protein: HLAE
HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)]

Gene: HLAE, HLA-E
Organism: Homo sapiens
Interactions: 76
UniProt ID: P13747

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001815 - positive regulation of antibody-dependent cellular cytotoxicity
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002250 - adaptive immune response
GO:0002476 - antigen processing and presentation of endogenous peptide antigen via MHC class Ib

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

533127

HLAF
HLA class I histocompatibility antigen, alpha chain F

4

16

Small-scale

0.908

High

488112

HLAC
HLA class I histocompatibility antigen, C alpha chain

3

16

High-throughput

0.861

High

533134

EPHB4
Ephrin type-B receptor 4

3

7

High-throughput

0.861

High

533157

HMR1
Major histocompatibility complex class I-related gene protein

3

16

High-throughput

0.861

High

533121

HLAG
HLA class I histocompatibility antigen, alpha chain G

2

16

High-throughput

0.811

High

533162

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

2

3

High-throughput

0.811

High

533136

FCGRN
IgG receptor FcRn large subunit p51

2

17

High-throughput

0.789

High

533144

KLRD1
Natural killer cells antigen CD94

2

20

Small-scale

0.768

High

533137

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

2

20

Small-scale

0.755

High

382286

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

15

High-throughput

0.737

High

354269

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

15

High-throughput

0.712

High

354630

HLAH
Putative HLA class I histocompatibility antigen, alpha chain H

2

15

High-throughput

0.712

High

532886

PRG2
Bone marrow proteoglycan

1

10

High-throughput

0.691

High

533138

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

18

High-throughput

0.691

High

533148

LRC24
Leucine-rich repeat-containing protein 24

1

5

High-throughput

0.691

High

533155

CLC2B
C-type lectin domain family 2 member B

1

20

High-throughput

0.691

High

533167

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

6

High-throughput

0.691

High

533174

BTNL2
Butyrophilin-like protein 2

1

6

High-throughput

0.691

High

318347

ECEL1
Endothelin-converting enzyme-like 1

3

4

High-throughput

0.667

High

533123

ITA6
Integrin alpha-6

3

1

High-throughput

0.667

High

533129

MA2A2
Alpha-mannosidase 2x

3

1

High-throughput

0.667

High

533130

PLXA3
Plexin-A3

3

7

High-throughput

0.667

High

533145

GAS6
Growth arrest-specific protein 6

3

1

High-throughput

0.667

High

533150

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

3

3

High-throughput

0.667

High

533151

WDFY3
WD repeat and FYVE domain-containing protein 3

3

3

High-throughput

0.667

High

533165

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

3

1

High-throughput

0.667

High

533169

CNTP3
Contactin-associated protein-like 3

3

1

High-throughput

0.667

High

533172

CNNM1
Metal transporter CNNM1

3

3

High-throughput

0.667

High

533142

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

3

0

High-throughput

0.638

High

533143

ASPH
Aspartyl/asparaginyl beta-hydroxylase

3

0

High-throughput

0.638

High

533177

BACE2
Beta-secretase 2

3

0

High-throughput

0.638

High

319703

HERC2
E3 ubiquitin-protein ligase HERC2

1

1

High-throughput

0.618

High

382578

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

20

High-throughput

0.618

High

533124

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

20

Small-scale

0.618

High

533125

NKG2C
NKG2-C type II integral membrane protein

1

20

Small-scale

0.618

High

533122

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

2

1

High-throughput

0.611

High

533132

NDST1
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

2

2

High-throughput

0.611

High

533131

NEK4
Serine/threonine-protein kinase Nek4

3

3

High-throughput

0.609

High

533159

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

3

2

High-throughput

0.609

High

533160

TECT2
Tectonic-2

3

4

High-throughput

0.609

High

533173

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

3

6

High-throughput

0.609

High

533126

CALR
Calreticulin

2

8

Small-scale

0.595

High

533179

ATP23
Mitochondrial inner membrane protease ATP23 homolog

2

0

High-throughput

0.585

High

354926

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

20

High-throughput

0.575

High

533161

PP16A
Protein phosphatase 1 regulatory subunit 16A

1

0

High-throughput

0.560

High

533135

PAR2
Proteinase-activated receptor 2

1

3

High-throughput

0.541

High

514334

PSPC
Surfactant protein C

1

4

High-throughput

0.536

High

528454

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

533120

PERF
Perforin-1

1

1

High-throughput

0.536

High

533140

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

18

High-throughput

0.536

High

533149

BRID5
BRICHOS domain-containing protein 5

1

4

High-throughput

0.536

High

533158

T106A
Transmembrane protein 106A

1

5

High-throughput

0.536

High

533163

SORT
Sortilin

1

1

High-throughput

0.536

High

533170

SEM6B
Semaphorin-6B

1

2

High-throughput

0.536

High

533175

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

1

12

High-throughput

0.536

High

533141

TAP2
Antigen peptide transporter 2

1

8

Small-scale

0.515

High

533171

UD17
UDP-glucuronosyltransferase 1A7

1

5

High-throughput

0.489

High

533176

DJC16
DnaJ homolog subfamily C member 16

1

9

High-throughput

0.489

High

165154

PLXB2
Plexin-B2

1

8

High-throughput

0.479

High

204986

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

533128

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

533133

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

2

High-throughput

0.479

High

533164

ABCA3
Phospholipid-transporting ATPase ABCA3

1

4

High-throughput

0.479

High

533166

CNPY3
Protein canopy homolog 3

1

1

Small-scale

0.479

High

533178

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

6

High-throughput

0.479

High

533147

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

1

0

High-throughput

0.458

High

533154

MADD
MAP kinase-activating death domain protein

1

0

High-throughput

0.458

High

483285

TPC2B
Trafficking protein particle complex subunit 2B

1

1

High-throughput

0.439

High

533156

TM131
Transmembrane protein 131

1

4

High-throughput

0.437

High

483230

TPC2A
Trafficking protein particle complex subunit 2

1

1

High-throughput

0.417

High

533152

EFNMT
eEF1A lysine and N-terminal methyltransferase

3

0

High-throughput

0.347

High

64415

RTL8C
Retrotransposon Gag-like protein 8C

2

0

High-throughput

0.318

High

533153

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

2

0

High-throughput

0.318

High

533146

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.279

Low

533139

EREP3
Protein ENTREP3

1

0

High-throughput

0.249

Low

533168

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024