Protein: HRG
Histidine-rich glycoprotein (Histidine-proline-rich glycoprotein) (HPRG)

Gene: HRG
Organism: Homo sapiens
Interactions: 58
UniProt ID: P04196

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0002839 - positive regulation of immune response to tumor cell
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0004869 - cysteine-type endopeptidase inhibitor activity
GO:0005102 - signaling receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

303097

RGS20
Regulator of G-protein signaling 20

3

1

High-throughput

0.665

High

180467

PLS1
Phospholipid scramblase 1

2

2

High-throughput

0.614

High

70079

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.606

High

158685

UTY
Histone demethylase UTY

1

3

High-throughput

0.536

High

210674

KLK10
Kallikrein-10

1

4

High-throughput

0.536

High

405598

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

405599

FBN1
Fibrillin-1 [Cleaved into: Asprosin]

1

3

High-throughput

0.536

High

405600

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

4

High-throughput

0.536

High

405606

P3H1
Prolyl 3-hydroxylase 1

1

5

High-throughput

0.536

High

405611

P3H3
Prolyl 3-hydroxylase 3

1

5

High-throughput

0.536

High

405612

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

4

High-throughput

0.536

High

405628

FBLN5
Fibulin-5

1

4

High-throughput

0.536

High

405630

PHF11
PHD finger protein 11

1

10

High-throughput

0.536

High

405631

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.536

High

405633

ING4
Inhibitor of growth protein 4

1

2

High-throughput

0.536

High

405620

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.529

High

405629

PRAF1
Prenylated Rab acceptor protein 1

1

0

High-throughput

0.518

High

64844

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.513

High

405597

GRN
Progranulin

1

0

High-throughput

0.513

High

405605

PP1R7
Protein phosphatase 1 regulatory subunit 7

1

0

High-throughput

0.513

High

405625

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

387680

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

1

Small-scale

0.501

High

291981

CRTAP
Cartilage-associated protein

1

5

High-throughput

0.489

High

405607

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

3

High-throughput

0.489

High

405613

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

5

High-throughput

0.489

High

405614

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.489

High

405616

SC65
Endoplasmic reticulum protein SC65

1

5

High-throughput

0.489

High

405621

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.489

High

388877

FINC
Fibronectin

1

4

High-throughput

0.481

High

405594

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

High-throughput

0.481

High

369232

ANT3
Antithrombin-III

1

1

High-throughput

0.479

High

370893

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

387932

FIBG
Fibrinogen gamma chain

1

1

Small-scale

0.479

High

405592

IC1
Plasma protease C1 inhibitor

1

2

High-throughput

0.479

High

405595

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

405601

BRPF1
Peregrin

1

4

High-throughput

0.479

High

405602

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

405608

JADE1
Protein Jade-1

1

4

High-throughput

0.479

High

405615

JADE3
Protein Jade-3

1

6

High-throughput

0.479

High

405617

KAT6A
Histone acetyltransferase KAT6A

1

3

High-throughput

0.479

High

405622

PCGF1
Polycomb group RING finger protein 1

1

5

High-throughput

0.479

High

405624

NANOG
Homeobox protein NANOG

1

9

High-throughput

0.479

High

405632

BRPF3
Bromodomain and PHD finger-containing protein 3

1

4

High-throughput

0.479

High

221310

SPY1
Protein sprouty homolog 1

1

0

High-throughput

0.460

High

369802

CO3
Complement C3

1

0

High-throughput

0.458

High

405626

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

0

Small-scale

0.458

High

277250

PITX3
Pituitary homeobox 3

1

7

Small-scale

0.437

High

405596

H2B1O
Histone H2B type 1-O

1

14

High-throughput

0.437

High

405603

CUL4A
Cullin-4A

1

2

High-throughput

0.437

High

405609

DPPA4
Developmental pluripotency-associated protein 4

1

2

High-throughput

0.437

High

405604

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

405610

STING
Stimulator of interferon genes protein

1

0

Small-scale

0.426

High

405593

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

405618

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

405619

MED30
Mediator of RNA polymerase II transcription subunit 30

1

0

High-throughput

0.279

Low

405627

IMPCT
Protein IMPACT

1

0

High-throughput

0.279

Low

405623

CHRD
Chordin

1

0

High-throughput

0.251

Low

405591

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025