Protein: XBP1
X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]

Gene: XBP1
Organism: Homo sapiens
Interactions: 46
UniProt ID: P17861

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

608954

XBP1
X-box-binding protein 1

4

18

Small-scale

0.885

High

608955

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

2

19

High-throughput

0.778

High

608990

ZHANG
CREB/ATF bZIP transcription factor

2

2

High-throughput

0.778

High

370547

FOS
Protein c-Fos

1

18

Small-scale

0.647

High

608987

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

20

High-throughput

0.647

High

608962

CEBPD
CCAAT/enhancer-binding protein delta

1

13

Small-scale

0.618

High

608971

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

2

2

High-throughput

0.606

High

395452

ESR1
Estrogen receptor

1

2

Small-scale

0.561

High

608960

PSA5
Proteasome subunit alpha type-5

1

3

Small-scale

0.561

High

608965

PSA6
Proteasome subunit alpha type-6

1

3

Small-scale

0.561

High

608966

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.552

High

608973

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

1

High-throughput

0.541

High

608967

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.537

High

608980

SPP
Signal peptide peptidase

1

1

Small-scale

0.534

High

238768

SSX4
Protein SSX4

1

0

High-throughput

0.518

High

455692

H10
Histone H1.0

1

0

High-throughput

0.518

High

466627

GLI1
Zinc finger protein GLI1

1

0

High-throughput

0.518

High

608964

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.518

High

608969

SRSF1
Serine/arginine-rich splicing factor 1

1

0

High-throughput

0.518

High

608970

RBL2
Retinoblastoma-like protein 2

1

0

High-throughput

0.518

High

608974

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.518

High

608978

ZN440
Zinc finger protein 440

1

0

High-throughput

0.518

High

608982

H1X
Histone H1.10

1

0

High-throughput

0.518

High

608986

FUBP3
Far upstream element-binding protein 3

1

0

High-throughput

0.518

High

608991

ZN580
Zinc finger protein 580

1

0

High-throughput

0.518

High

608988

DERL1
Derlin-1

1

1

Small-scale

0.515

High

608976

CROCC
Rootletin

1

0

High-throughput

0.513

High

608977

C102B
Coiled-coil domain-containing protein 102B

1

0

High-throughput

0.513

High

608975

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.512

High

165252

PSA7
Proteasome subunit alpha type-7

1

3

Small-scale

0.501

High

608956

NFYA
Nuclear transcription factor Y subunit alpha

1

3

Small-scale

0.479

High

608958

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.479

High

608968

PO5F1
POU domain, class 5, transcription factor 1

1

1

Small-scale

0.479

High

608972

NFYC
Nuclear transcription factor Y subunit gamma

1

4

Small-scale

0.479

High

608979

PSMA8
Proteasome subunit alpha-type 8

1

3

Small-scale

0.479

High

608981

RN139
E3 ubiquitin-protein ligase RNF139

1

3

Small-scale

0.479

High

608983

KAT2A
Histone acetyltransferase KAT2A

1

3

Small-scale

0.479

High

608984

KAT2B
Histone acetyltransferase KAT2B

1

3

Small-scale

0.479

High

608985

FBXW7
F-box/WD repeat-containing protein 7

1

2

Small-scale

0.479

High

608957

NFYB
Nuclear transcription factor Y subunit beta

1

0

Small-scale

0.458

High

608959

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

Small-scale

0.458

High

608963

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

608989

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

1

0

High-throughput

0.282

High

608961

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.265

Low

105289

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025