HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: TBB4B (P68371)
Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain)
Gene: TUBB4B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0046872 - metal ion binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 445
+	Hs
		374186 RAF1_HUMAN (1-648): 0: 652: 100.00		TBB3_HUMAN (1-443): 0: 714: 93.23
+	Hs
		373536 RAF1_HUMAN (1-648): 0: 652: 100.00		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		373490 RAF1_HUMAN (1-648): 0: 652: 100.00		TBB4A_HUMAN (1-427): 0: 706: 98.60
+	Hs
		374799 RAF1_HUMAN (1-648): 0: 652: 100.00		TBB6_HUMAN (1-432): 0: 706: 92.36
+	Hs
		427981 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		488672 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		TBB4B_HUMAN (1-427): 0: 711: 100.00
+	Hs
		488795 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		TBB6_HUMAN (1-432): 0: 706: 92.36
+	Dm
		445193 KRAF1_DROME (45-647): 6.35e-165: 491: 44.98		TBB3_DROME (1-445): 0: 698: 89.14
+	Dm
		507732 KRAF1_DROME (45-647): 6.35e-165: 491: 44.98		Q8MST5_DROME (1-445): 0: 696: 88.09
+	Hs
		427991 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		TBB5_HUMAN (1-429): 0: 711: 98.37