Protein: M4K2
Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)

Gene: M4K2, MAP4K2
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q12851

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006468 - protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1087650

M3K1
Mitogen-activated protein kinase kinase kinase 1

2

19

Small-scale

0.789

High

349055

LATS1
Serine/threonine-protein kinase LATS1

2

20

Small-scale

0.778

High

955923

RAB8A
Ras-related protein Rab-8A

1

9

Small-scale

0.713

High

1087649

STK3
Serine/threonine-protein kinase 3

1

16

High-throughput

0.691

High

1087657

CDC37
Hsp90 co-chaperone Cdc37

1

9

High-throughput

0.691

High

1087678

CDKL2
Cyclin-dependent kinase-like 2

1

11

High-throughput

0.691

High

1087681

SRPK1
SRSF protein kinase 1

1

17

High-throughput

0.691

High

1087659

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

11

Small-scale

0.665

High

650721

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

9

High-throughput

0.656

High

853884

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

18

Small-scale

0.647

High

461410

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468310

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

947177

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

4

High-throughput

0.618

High

1023223

RBM3
RNA-binding protein 3

1

4

High-throughput

0.618

High

1060949

SRSF1
Serine/arginine-rich splicing factor 1

1

6

High-throughput

0.618

High

1087362

GRSF1
G-rich sequence factor 1

1

7

High-throughput

0.618

High

1087652

G3BP1
Ras GTPase-activating protein-binding protein 1

1

9

High-throughput

0.618

High

1087654

CIRBP
Cold-inducible RNA-binding protein

1

7

High-throughput

0.618

High

1087656

RNPS1
RNA-binding protein with serine-rich domain 1

1

4

High-throughput

0.618

High

1087660

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

10

High-throughput

0.618

High

1087668

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

15

High-throughput

0.618

High

1087680

AURKB
Aurora kinase B

1

17

High-throughput

0.618

High

1087705

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

17

High-throughput

0.618

High

1087655

NAA30
N-alpha-acetyltransferase 30

2

2

High-throughput

0.601

High

1087658

U1SBP
U11/U12 small nuclear ribonucleoprotein 35 kDa protein

1

3

High-throughput

0.587

High

327976

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

16

High-throughput

0.561

High

952135

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

16

High-throughput

0.561

High

1087647

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.561

High

471820

RU2B
U2 small nuclear ribonucleoprotein B''

1

8

High-throughput

0.553

High

1029461

SRSF2
Serine/arginine-rich splicing factor 2

1

3

High-throughput

0.553

High

1087651

SRSF9
Serine/arginine-rich splicing factor 9

1

9

High-throughput

0.553

High

1087683

RBM4B
RNA-binding protein 4B

1

4

High-throughput

0.553

High

1087691

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

High-throughput

0.553

High

1087702

SF3B6
Splicing factor 3B subunit 6

1

9

High-throughput

0.553

High

155846

DPYL4
Dihydropyrimidinase-related protein 4

2

6

High-throughput

0.549

High

1087687

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

16

High-throughput

0.512

High

176765

NACAD
NAC-alpha domain-containing protein 1

1

5

High-throughput

0.508

High

558079

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.508

High

1087693

STRN4
Striatin-4

1

20

High-throughput

0.501

High

948732

DEFB1
Beta-defensin 1

1

0

High-throughput

0.486

High

791345

SYUA
Alpha-synuclein

1

5

High-throughput

0.481

High

276303

HMMR
Hyaluronan mediated motility receptor

1

20

High-throughput

0.479

High

286961

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

7

High-throughput

0.479

High

643464

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

3

High-throughput

0.479

High

903066

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

2

High-throughput

0.479

High

985448

RL32
Large ribosomal subunit protein eL32

1

3

High-throughput

0.479

High

1087661

PDZ11
PDZ domain-containing protein 11

1

14

High-throughput

0.479

High

1087665

LN28B
Protein lin-28 homolog B

1

6

High-throughput

0.479

High

1087666

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

12

High-throughput

0.479

High

1087667

LUZP1
Leucine zipper protein 1

1

20

High-throughput

0.479

High

1087682

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

5

High-throughput

0.479

High

1087685

PYM1
Partner of Y14 and mago

1

1

High-throughput

0.479

High

1087688

DDX47
Probable ATP-dependent RNA helicase DDX47

1

9

High-throughput

0.479

High

1087698

DDX41
Probable ATP-dependent RNA helicase DDX41

1

6

High-throughput

0.479

High

1087700

RTRAF
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.479

High

1087704

RL36
Large ribosomal subunit protein eL36

1

2

High-throughput

0.479

High

714726

KAIN
Kallistatin

1

2

High-throughput

0.464

High

1087648

PRDX4
Peroxiredoxin-4

1

5

High-throughput

0.464

High

1087662

SPOUT
28S rRNA

1

0

High-throughput

0.458

High

1087673

CHSTE
Carbohydrate sulfotransferase 14

1

0

High-throughput

0.458

High

1087679

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

High-throughput

0.458

High

429795

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

125946

SMAP
Small acidic protein

1

2

High-throughput

0.437

High

126098

AP3B1
AP-3 complex subunit beta-1

1

5

High-throughput

0.437

High

209256

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

10

High-throughput

0.437

High

485614

RU2A
U2 small nuclear ribonucleoprotein A'

1

7

High-throughput

0.437

High

621634

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.437

High

1024022

TFAM
Transcription factor A, mitochondrial

1

4

High-throughput

0.437

High

1087653

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.437

High

1087664

RM14
Large ribosomal subunit protein uL14m

1

1

High-throughput

0.437

High

1087669

PHF6
PHD finger protein 6

1

5

High-throughput

0.437

High

1087675

TFB1M
Dimethyladenosine transferase 1, mitochondrial

1

1

High-throughput

0.437

High

1087676

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

2

High-throughput

0.437

High

1087684

CHOLN
Protein cholesin

1

1

High-throughput

0.437

High

1087686

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.437

High

1087689

CH033
UPF0488 protein C8orf33

1

1

High-throughput

0.437

High

1087690

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

4

High-throughput

0.437

High

1087695

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

3

High-throughput

0.437

High

1087696

RCC2
Protein RCC2

1

6

High-throughput

0.437

High

1087697

TRM6
tRNA

1

1

High-throughput

0.437

High

1087699

DIM1
Dimethyladenosine transferase

1

1

High-throughput

0.437

High

1087701

AP3M1
AP-3 complex subunit mu-1

1

2

High-throughput

0.437

High

1087703

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.437

High

1087694

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.299

High

258512

KIN17
DNA/RNA-binding protein KIN17

1

0

High-throughput

0.249

Low

455757

H10
Histone H1.0

1

0

High-throughput

0.249

Low

641767

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.249

Low

643809

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.249

Low

711634

3MG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.249

Low

912054

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.249

Low

974532

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.249

Low

1087663

RM54
Large ribosomal subunit protein mL54

1

0

High-throughput

0.249

Low

1087670

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.249

Low

1087671

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.249

Low

1087672

RP25L
Ribonuclease P protein subunit p25-like protein

1

0

High-throughput

0.249

Low

1087674

BRX1
Ribosome biogenesis protein BRX1 homolog

1

0

High-throughput

0.249

Low

1087677

RTF1
RNA polymerase-associated protein RTF1 homolog

1

0

High-throughput

0.249

Low

1087692

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025