HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: SHPS1 (P78324)
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
Gene: SIRPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 504
+	Hs
		373874 RASN_HUMAN (1-188): 4.47e-88: 257: 85.64		SHPS1_HUMAN (1-504): 1.95e-109: 336: 100.00
+	Hs
		375390 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		SHPS1_HUMAN (1-504): 1.95e-109: 336: 100.00
+	Hs
		375500 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		CD166_HUMAN (1-312): 3.84e-54: 193: 18.62
+	Hs
		374079 RASN_HUMAN (1-188): 4.47e-88: 257: 85.64		CADM4_HUMAN (38-426): 1.71e-50: 179: 16.92
+	Hs
		374584 RASH_HUMAN (16-189): 6.27e-73: 219: 100.00		CD166_HUMAN (1-312): 3.84e-54: 193: 18.62
+	Hs
		224534 RASH_HUMAN (16-189): 6.27e-73: 219: 100.00		SIGL6_HUMAN (25-503): 6.04e-52: 184: 13.94
+	Hs
		374318 RASN_HUMAN (1-188): 4.47e-88: 257: 85.64		ROBO1_HUMAN (24-496): 4.16e-25: 111: 12.27
+	Hs
		376163 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		ROBO1_HUMAN (24-496): 4.16e-25: 111: 12.27
+	Hs
		375909 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		CADM1_HUMAN (41-289): 2.78e-25: 109: 21.18
+	Hs
		375974 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		ROBO2_HUMAN (24-487): 1.83e-22: 103: 11.81
+	Hs
		374138 RASN_HUMAN (1-188): 4.47e-88: 257: 85.64		KIRR1_HUMAN (149-492): 5.34e-18: 89.4: 12.39
+	Hs
		375842 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		KIRR1_HUMAN (149-492): 5.34e-18: 89.4: 12.39
+	Hs
		976711 RB11A_HUMAN (4-178): 6.31e-73: 220: 33.90		ROBO1_HUMAN (24-496): 4.16e-25: 111: 12.27
+	Hs
		375059 RASH_HUMAN (16-189): 6.27e-73: 219: 100.00		ROBO1_HUMAN (24-496): 4.16e-25: 111: 12.27
+	Hs
		374901 RASH_HUMAN (16-189): 6.27e-73: 219: 100.00		CADM1_HUMAN (41-289): 2.78e-25: 109: 21.18
+	Hs
		375784 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		TITIN_HUMAN (65-451): 2.63e-09: 62.4: 7.73
+	Hs
		976484 RB11A_HUMAN (4-178): 6.31e-73: 220: 33.90		KIRR1_HUMAN (149-492): 5.34e-18: 89.4: 12.39
+	Hs
		374855 RASH_HUMAN (16-189): 6.27e-73: 219: 100.00		KIRR1_HUMAN (149-492): 5.34e-18: 89.4: 12.39
+	Hs
		976456 RB11A_HUMAN (4-178): 6.31e-73: 220: 33.90		TITIN_HUMAN (65-451): 2.63e-09: 62.4: 7.73
+	Hs
		957983 RAB14_HUMAN (4-180): 2.65e-71: 216: 29.05		TITIN_HUMAN (65-451): 2.63e-09: 62.4: 7.73