Protein: CD166
CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)

Gene: CD166, ALCAM
Organism: Homo sapiens
Interactions: 81
UniProt ID: Q13740

Gene Ontology (top 5):
GO:0001772 - immunological synapse
GO:0002250 - adaptive immune response
GO:0005102 - signaling receptor binding
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

609673

LEG3
Galectin-3

5

13

Small-scale

0.716

High

1116952

CD166
CD166 antigen

1

18

Small-scale

0.716

High

718396

CD6
T-cell differentiation antigen CD6

4

4

Small-scale

0.708

High

480787

LEG1
Galectin-1

4

13

Small-scale

0.704

High

1116956

UBR4
E3 ubiquitin-protein ligase UBR4

3

3

High-throughput

0.640

High

125444

LEG9
Galectin-9

4

13

High-throughput

0.633

High

423774

APOD
Apolipoprotein D

2

1

High-throughput

0.628

High

1116979

PCD12
Protocadherin-12

2

2

High-throughput

0.628

High

411898

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

774341

BASI
Basigin

1

19

High-throughput

0.618

High

845633

MUC18
Cell surface glycoprotein MUC18

1

19

High-throughput

0.618

High

1116954

CAH9
Carbonic anhydrase 9

1

3

High-throughput

0.618

High

1116953

RAB35
Ras-related protein Rab-35

2

9

High-throughput

0.611

High

127327

LEG8
Galectin-8

3

13

High-throughput

0.609

High

948818

CD81
CD81 antigen

2

16

Small-scale

0.601

High

160180

CHD2
Chromodomain-helicase-DNA-binding protein 2

3

1

High-throughput

0.585

High

1116982

FBX2
F-box only protein 2

2

9

High-throughput

0.574

High

631207

RAB5A
Ras-related protein Rab-5A

2

10

High-throughput

0.571

High

641949

CD9
CD9 antigen

2

16

Small-scale

0.571

High

1116967

SH2D3
SH2 domain-containing protein 3C

2

18

High-throughput

0.571

High

363257

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.554

High

1116964

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.553

High

139213

UPK2
Uroplakin-2

1

2

High-throughput

0.536

High

462873

LAMB1
Laminin subunit beta-1

1

12

High-throughput

0.536

High

698642

CALX
Calnexin

1

8

High-throughput

0.536

High

753808

MRP1
Multidrug resistance-associated protein 1

1

1

High-throughput

0.536

High

761221

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.536

High

821677

TPOR
Thrombopoietin receptor

1

1

High-throughput

0.536

High

1116957

SYT6
Synaptotagmin-6

1

2

High-throughput

0.536

High

1116973

PD1L2
Programmed cell death 1 ligand 2

1

20

High-throughput

0.536

High

1116974

TMPSD
Transmembrane protease serine 13

1

5

High-throughput

0.536

High

1116983

CLC4A
C-type lectin domain family 4 member A

1

11

High-throughput

0.536

High

1108504

NAR3
Ecto-ADP-ribosyltransferase 3

1

0

High-throughput

0.518

High

1116985

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

1116959

HPHL1
Ferroxidase HEPHL1

1

0

High-throughput

0.493

High

1063235

GOGA2
Golgin subfamily A member 2

1

5

High-throughput

0.489

High

1116955

LEG9B
Galectin-9B

1

13

High-throughput

0.489

High

1116984

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

3

High-throughput

0.489

High

189557

STX7
Syntaxin-7

1

8

High-throughput

0.479

High

218162

TGON2
Trans-Golgi network integral membrane protein 2

1

9

High-throughput

0.479

High

341049

DIRA3
GTP-binding protein Di-Ras3

1

9

High-throughput

0.479

High

374584

RASH
GTPase HRas

1

20

High-throughput

0.479

High

375500

RASK
GTPase KRas

1

20

High-throughput

0.479

High

410828

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.479

High

537126

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

603780

ITA2
Integrin alpha-2

1

4

Small-scale

0.479

High

900804

RAB5C
Ras-related protein Rab-5C

1

10

High-throughput

0.479

High

901802

RAB9A
Ras-related protein Rab-9A

1

11

High-throughput

0.479

High

940352

ITA1
Integrin alpha-1

1

4

Small-scale

0.479

High

953434

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

956284

RAB2A
Ras-related protein Rab-2A

1

10

High-throughput

0.479

High

975025

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

977993

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

1116965

CXD3
Gap junction delta-3 protein

1

9

High-throughput

0.479

High

1116971

CK052
Uncharacterized protein C11orf52

1

4

High-throughput

0.479

High

1116975

ACE2
Angiotensin-converting enzyme 2

1

3

Small-scale

0.479

High

349416

TSN15
Tetraspanin-15

1

15

High-throughput

0.445

High

529765

TAU
Microtubule-associated protein tau

1

11

High-throughput

0.445

High

967304

TSN5
Tetraspanin-5

1

15

High-throughput

0.445

High

105898

APRIO
Alternative prion protein

1

10

High-throughput

0.437

High

320972

SUN1
SUN domain-containing protein 1

1

1

High-throughput

0.437

High

418115

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.437

High

1004542

RNF4
E3 ubiquitin-protein ligase RNF4

1

10

High-throughput

0.437

High

1116961

OGFD3
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

1

1

High-throughput

0.437

High

1116969

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

7

High-throughput

0.437

High

1116970

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.437

High

1116980

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.437

High

1116981

XPO7
Exportin-7

1

2

High-throughput

0.437

High

1116958

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.279

Low

1116962

PAQR3
Progestin and adipoQ receptor family member 3

1

0

High-throughput

0.279

Low

1116966

MESH1
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

1

0

High-throughput

0.279

Low

1116968

THAP8
THAP domain-containing protein 8

1

0

High-throughput

0.279

Low

1116978

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.279

Low

1116972

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.269

Low

915442

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.249

Low

958942

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low

1116960

CDC73
Parafibromin

1

0

High-throughput

0.249

Low

1116963

SOSD1
Sclerostin domain-containing protein 1

1

0

Small-scale

0.249

Low

1116977

AAMDC
Mth938 domain-containing protein

1

0

High-throughput

0.249

Low

1116976

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025