Protein: SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)

Gene: SHPS1, SIRPA
Organism: Homo sapiens
Interactions: 88
UniProt ID: P78324

Gene Ontology (top 5):
GO:0004864 - protein phosphatase inhibitor activity
GO:0005886 - plasma membrane
GO:0007155 - cell adhesion
GO:0009986 - cell surface
GO:0010468 - regulation of gene expression

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1005355

CD47
Leukocyte surface antigen CD47

3

3

Small-scale

0.870

High

1005377

SIRPG
Signal-regulatory protein gamma

3

18

High-throughput

0.855

High

128553

SIRB1
Signal-regulatory protein beta-1

3

17

High-throughput

0.847

High

375390

RASK
GTPase KRas

3

20

High-throughput

0.827

High

262154

NOL3
Nucleolar protein 3

2

0

High-throughput

0.751

High

465484

IGF1R
Insulin-like growth factor 1 receptor

1

15

Small-scale

0.724

High

728164

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.724

High

821307

TCPZ
T-complex protein 1 subunit zeta

1

1

Small-scale

0.724

High

1005354

SOS1
Son of sevenless homolog 1

1

2

Small-scale

0.724

High

1005353

PTN11
Tyrosine-protein phosphatase non-receptor type 11

5

8

Small-scale

0.721

High

840847

MATK
Megakaryocyte-associated tyrosine-protein kinase

3

4

Small-scale

0.693

High

1005378

CLC4A
C-type lectin domain family 4 member A

1

6

High-throughput

0.691

High

684191

DDX6
Probable ATP-dependent RNA helicase DDX6

1

0

Small-scale

0.687

High

1005359

ILK
Scaffold protein ILK

1

0

Small-scale

0.687

High

1005375

NOX4
NADPH oxidase 4

1

0

Small-scale

0.687

High

459539

PROF1
Profilin-1

1

1

Small-scale

0.647

High

551850

CO6A2

1

7

Small-scale

0.647

High

555662

ACTN1
Alpha-actinin-1

1

4

Small-scale

0.647

High

948780

CD81
CD81 antigen

1

11

Small-scale

0.647

High

1005350

CDK16
Cyclin-dependent kinase 16

1

4

Small-scale

0.647

High

1005356

NEXN
Nexilin

1

19

Small-scale

0.647

High

1005370

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

1

Small-scale

0.647

High

373874

RASN
GTPase NRas

1

20

High-throughput

0.618

High

374517

RASH
GTPase HRas

1

20

High-throughput

0.618

High

556008

CADH1
Cadherin-1

1

4

High-throughput

0.618

High

845594

MUC18
Cell surface glycoprotein MUC18

1

17

High-throughput

0.618

High

977926

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1005357

ANK3
Ankyrin-3

1

3

High-throughput

0.618

High

1005374

TRIM2
Tripartite motif-containing protein 2

3

7

High-throughput

0.599

High

711093

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

8

Small-scale

0.594

High

571926

TRI27
Zinc finger protein RFP

1

0

High-throughput

0.589

High

1005363

K1H1
Keratin, type I cuticular Ha1

2

12

High-throughput

0.584

High

1005358

DDX10
Probable ATP-dependent RNA helicase DDX10

1

2

Small-scale

0.579

High

1005372

NEK1
Serine/threonine-protein kinase Nek1

1

5

Small-scale

0.579

High

468259

HS90B
Heat shock protein HSP 90-beta

1

2

Small-scale

0.561

High

474612

VIME
Vimentin

1

6

Small-scale

0.561

High

534924

BIP
Endoplasmic reticulum chaperone BiP

1

9

Small-scale

0.561

High

573429

ENPL
Endoplasmin

1

2

Small-scale

0.561

High

614677

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

4

Small-scale

0.561

High

697838

CALR
Calreticulin

1

9

Small-scale

0.561

High

801261

HSPA9
Stress-70 protein, mitochondrial

1

10

Small-scale

0.561

High

838052

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

2

Small-scale

0.561

High

1005368

KTN1
Kinectin

1

5

Small-scale

0.561

High

1005366

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.553

High

391605

FRIH
Ferritin heavy chain

1

0

Small-scale

0.537

High

567370

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.537

High

867037

CAPZB
F-actin-capping protein subunit beta

1

0

Small-scale

0.537

High

987529

GRB2
Growth factor receptor-bound protein 2

1

5

High-throughput

0.536

High

1005373

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.536

High

1005364

CCD57
Coiled-coil domain-containing protein 57

2

3

High-throughput

0.533

High

536949

HSP7C
Heat shock cognate 71 kDa protein

1

2

Small-scale

0.501

High

566128

K1C10
Keratin, type I cytoskeletal 10

1

9

Small-scale

0.501

High

612192

ARF4
ADP-ribosylation factor 4

1

6

Small-scale

0.501

High

637450

FLNA
Filamin-A

1

9

Small-scale

0.501

High

761632

HSP74
Heat shock 70 kDa protein 4

1

3

Small-scale

0.501

High

777440

K22E
Keratin, type II cytoskeletal 2 epidermal

1

6

Small-scale

0.501

High

954787

PSA6
Proteasome subunit alpha type-6

1

2

Small-scale

0.501

High

968876

PRS8
26S proteasome regulatory subunit 8

1

1

Small-scale

0.501

High

1005360

SAFB2
Scaffold attachment factor B2

1

6

Small-scale

0.501

High

164853

SH21B
SH2 domain-containing protein 1B

1

11

High-throughput

0.489

High

618018

K1C15
Keratin, type I cytoskeletal 15

1

9

High-throughput

0.481

High

783233

TRI23
E3 ubiquitin-protein ligase TRIM23

1

7

High-throughput

0.481

High

290914

PPM1B
Protein phosphatase 1B

1

0

Small-scale

0.480

High

633368

MX1
Interferon-induced GTP-binding protein Mx1

1

0

Small-scale

0.480

High

969169

RS8
Small ribosomal subunit protein eS8

1

0

Small-scale

0.480

High

1005351

NUCB1
Nucleobindin-1

1

0

Small-scale

0.480

High

253337

JAK2
Tyrosine-protein kinase JAK2

1

9

Small-scale

0.479

High

711304

SHC1
SHC-transforming protein 1

1

5

Small-scale

0.479

High

1005352

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

1

High-throughput

0.479

High

258103

IF2P
Eukaryotic translation initiation factor 5B

1

1

Small-scale

0.457

High

767046

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

5

Small-scale

0.457

High

1005361

ELOA1
Elongin-A

1

3

Small-scale

0.457

High

1005362

ARHG6
Rho guanine nucleotide exchange factor 6

1

2

Small-scale

0.457

High

300335

KRT34
Keratin, type I cuticular Ha4

1

10

High-throughput

0.439

High

1005365

K1C40
Keratin, type I cytoskeletal 40

1

10

High-throughput

0.439

High

105739

APRIO
Alternative prion protein

1

8

High-throughput

0.437

High

1004434

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.437

High

843478

HD
Huntingtin

1

4

High-throughput

0.407

High

1005367

SPT6H
Transcription elongation factor SPT6

1

0

Small-scale

0.292

High

1005376

F1142
Protein FAM114A2

1

0

High-throughput

0.279

Low

165764

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

Small-scale

0.261

Low

787491

GNL1
Guanine nucleotide-binding protein-like 1

1

0

Small-scale

0.261

Low

178489

TBX3
T-box transcription factor TBX3

1

0

Small-scale

0.261

Low

397597

NU1M
NADH-ubiquinone oxidoreductase chain 1

1

0

Small-scale

0.261

Low

1005369

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

Small-scale

0.261

Low

1005371

FUBP1
Far upstream element-binding protein 1

1

0

Small-scale

0.261

Low

269174

HSF2B
Heat shock factor 2-binding protein

1

0

High-throughput

0.251

Low

991828

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025