HitPredict

Interactor 1: DRB1 (P01911)
HLA class II histocompatibility antigen, DRB1 beta chain (Human leukocyte antigen DRB1) (HLA-DRB1)
Gene: HLA-DRB1

Interactor 2: HG2A (P04233)
HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]
Gene: CD74

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.33 1.00 0.575

The method score is based on:

Property Details
Experiments 33961781
Identification Methods anti tag coimmunoprecipitation
Interaction Type association

The annotation score is based on:

Property Details
Interacting Pfam domains C1-set~MHC2-interact, MHC2-interact~MHC_II_beta
Common GO terms GO:0000139 - Golgi membrane
GO:0001934 - positive regulation of protein phosphorylation
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane
GO:0009897 - external side of plasma membrane
and 20 others

more...
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 266
Hs

1 296
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 11Aug2025