HitPredict

Interactor 1: VWF (P04275)
von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)]
Gene: VWF

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	21988832
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007155 - cell adhesion GO:0009611 - response to wounding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2813 Hs			1 192
+	Hs
		804195 NOTC1_HUMAN (561-1278): 3.4e-10: 68.5: 10.95		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		925219 NOTC2_HUMAN (293-1051): 1.17e-09: 66.6: 10.70		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564446 NOTC1_HUMAN (561-1278): 3.4e-10: 68.5: 10.95		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		564491 NOTC2_HUMAN (293-1051): 1.17e-09: 66.6: 10.70		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		545253 NOTC1_HUMAN (561-1278): 3.4e-10: 68.5: 10.95		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		545337 NOTC2_HUMAN (293-1051): 1.17e-09: 66.6: 10.70		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		545290 ITA1_HUMAN (1677-1802): 2.92e-09: 65.1: 32.56		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		804343 NOTC1_HUMAN (561-1278): 3.4e-10: 68.5: 10.95		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		980532 NOTC2_HUMAN (293-1051): 1.17e-09: 66.6: 10.70		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		804186 NOTC1_HUMAN (561-1278): 3.4e-10: 68.5: 10.95		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		804203 NOTC1_HUMAN (561-1278): 3.4e-10: 68.5: 10.95		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		892331 NOTC2_HUMAN (293-1051): 1.17e-09: 66.6: 10.70		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		950942 NOTC2_HUMAN (293-1051): 1.17e-09: 66.6: 10.70		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		804187 NOTC1_HUMAN (561-1278): 3.4e-10: 68.5: 10.95		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		893926 NOTC2_HUMAN (293-1051): 1.17e-09: 66.6: 10.70		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		804189 NOTC1_HUMAN (561-1278): 3.4e-10: 68.5: 10.95		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		900403 NOTC2_HUMAN (293-1051): 1.17e-09: 66.6: 10.70		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436195 NOTC1_HUMAN (561-1278): 3.4e-10: 68.5: 10.95		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		436267 NOTC2_HUMAN (293-1051): 1.17e-09: 66.6: 10.70		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		436228 ITA1_HUMAN (1677-1802): 2.92e-09: 65.1: 32.56		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45