HitPredict

Interactor 1: H2B1 (P02293)
Histone H2B.1 (Suppressor of Ty protein 12)
Gene: HTB1

Interactor 2: BRE1 (Q07457)
E3 ubiquitin-protein ligase BRE1 (EC 2.3.2.27) (Brefeldin A-sensitivity protein 1) (RING-type E3 ubiquitin transferase BRE1)
Gene: BRE1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.937

Property	Details
Experiments	25548288, 27601672, 37230987, 37633270, 37034759
Identification Methods	pull down, enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 131 Sc			1 700
+	Sc
		381651 H2B2_YEAST (1-131): 1.47e-45: 146: 96.95		BRE1_YEAST (1-700): 6.36e-50: 187: 100.00
+	Hs
		1208915 H2B2F_HUMAN (7-128): 7.24e-47: 149: 70.97		MRCKB_HUMAN (67-632): 2.5e-38: 155: 12.56
+	Hs
		1372353 H2B1H_HUMAN (7-128): 3.91e-46: 147: 70.97		MRCKB_HUMAN (67-632): 2.5e-38: 155: 12.56
+	Hs
		1162976 H2B2E_HUMAN (7-128): 3.7e-46: 147: 70.97		BRE1A_HUMAN (51-700): 1.84e-34: 143: 13.64
+	Hs
		272671 H2B2E_HUMAN (7-128): 3.7e-46: 147: 70.97		BRE1B_HUMAN (315-700): 1.64e-34: 143: 20.73
+	Hs
		272620 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		BRE1B_HUMAN (315-700): 1.64e-34: 143: 20.73
+	Hs
		754874 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		BRE1A_HUMAN (51-700): 1.84e-34: 143: 13.64
+	Hs
		256789 H2B1K_HUMAN (7-128): 1.07e-45: 146: 70.16		MYH11_HUMAN (4-552): 9.83e-20: 96.9: 10.57
+	Hs
		1372339 H2B1H_HUMAN (7-128): 3.91e-46: 147: 70.97		MYH2_HUMAN (252-663): 1.07e-16: 87: 12.08
+	Hs
		663822 H2B1H_HUMAN (7-128): 3.91e-46: 147: 70.97		LAMA2_HUMAN (324-642): 3.66e-13: 75.4: 12.22
+	Hs
		773242 H2B1H_HUMAN (7-128): 3.91e-46: 147: 70.97		MYH10_HUMAN (10-357): 1.7e-12: 73.2: 8.26
+	Hs
		256787 H2B1K_HUMAN (7-128): 1.07e-45: 146: 70.16		MYH10_HUMAN (10-357): 1.7e-12: 73.2: 8.26
+	Hs
		773151 H2B1C_HUMAN (7-128): 6.83e-46: 146: 70.97		MYH10_HUMAN (10-357): 1.7e-12: 73.2: 8.26
+	Hs
		157148 H2BFS_HUMAN (7-128): 4.81e-46: 147: 68.55		CTRO_HUMAN (149-643): 9.62e-11: 67.7: 14.74
+	Hs
		156752 H2B1K_HUMAN (7-128): 1.07e-45: 146: 70.16		CTRO_HUMAN (149-643): 9.62e-11: 67.7: 14.74
+	Hs
		156849 H2B1J_HUMAN (7-128): 5.8e-46: 146: 70.16		CTRO_HUMAN (149-643): 9.62e-11: 67.7: 14.74
+	Hs
		587760 H2B1H_HUMAN (7-128): 3.91e-46: 147: 70.97		DESP_HUMAN (127-645): 9.9e-10: 64.2: 14.61
+	Hs
		772943 H2B1H_HUMAN (7-128): 3.91e-46: 147: 70.97		MYH9_HUMAN (1-311): 9.55e-09: 61.2: 8.68
+	Hs
		256786 H2B1K_HUMAN (7-128): 1.07e-45: 146: 70.16		MYH9_HUMAN (1-311): 9.55e-09: 61.2: 8.68
+	Hs
		772718 H2B1C_HUMAN (7-128): 6.83e-46: 146: 70.97		MYH9_HUMAN (1-311): 9.55e-09: 61.2: 8.68