HitPredict

Interactor 1: CRYAB (P02511)
Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)
Gene: CRYAB

Interactor 2: HSPB1 (P04792)
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)
Gene: HSPB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 28919577, 11700327, 38334954, 17916631, 18330356, 26186194, 28514442, 1560006, 33961781, 12601044, 20863832, 23188086, 23532854, unassigned3799
Identification Methods pull down, two hybrid, cross-linking study, affinity chromatography technology, biochemical, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, nuclear magnetic resonance
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Crystallin~HSP20, HSP20~HSP20
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0009408 - response to heat
GO:0030018 - Z disc
and 5 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 175
Hs

1 205
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Last updated: 11Aug2025