HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: DSC2 (Q02487)
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)
Gene: DSC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 901
+	Hs
		971016 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		508000 FGFR1_HUMAN (195-794): 0: 545: 26.34		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		1055826 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		507817 FGFR1_HUMAN (195-794): 0: 545: 26.34		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		384674 NTRK1_HUMAN (1-796): 0: 621: 100.00		DSG1_HUMAN (130-573): 2.65e-65: 239: 33.18
+	Hs
		384238 NTRK1_HUMAN (1-796): 0: 621: 100.00		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		384720 NTRK1_HUMAN (1-796): 0: 621: 100.00		DSC1_HUMAN (4-464): 2.89e-45: 178: 14.46
+	Hs
		507842 FGFR1_HUMAN (195-794): 0: 545: 26.34		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		508295 FGFR1_HUMAN (195-794): 0: 545: 26.34		PCDA8_HUMAN (358-864): 2.34e-50: 193: 13.02
+	Hs
		385795 NTRK1_HUMAN (1-796): 0: 621: 100.00		PCDB3_HUMAN (517-878): 1.66e-23: 108: 9.66
+	Hs
		507929 FGFR1_HUMAN (195-794): 0: 545: 26.34		CAD11_HUMAN (4-349): 8.21e-46: 178: 18.78
+	Hs
		580237 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		384817 NTRK1_HUMAN (1-796): 0: 621: 100.00		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Xl
		292719 FGFR1_XENLA (195-794): 2.35e-179: 536: 26.18		O93264_XENLA (4-345): 2.86e-43: 171: 19.07
+	Hs
		434321 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		PCDGH_HUMAN (1-464): 7.02e-94: 318: 16.74
+	Hs
		507992 FGFR1_HUMAN (195-794): 0: 545: 26.34		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		1048593 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		607964 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		601509 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		434134 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55