HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 937
+	Hs
		384728 NTRK1_HUMAN (1-796): 0: 621: 100.00		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		507940 FGFR1_HUMAN (195-794): 0: 545: 26.34		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		1014018 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		321460 NTRK1_HUMAN (1-796): 0: 621: 100.00		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Hs
		302086 NTRK1_HUMAN (1-796): 0: 621: 100.00		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Hs
		384548 NTRK1_HUMAN (1-796): 0: 621: 100.00		COPB_HUMAN (8-927): 0: 561: 12.47
+	Hs
		321475 FGFR1_HUMAN (195-794): 0: 545: 26.34		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Hs
		119906 NTRK1_HUMAN (1-796): 0: 621: 100.00		AP3B1_HUMAN (8-594): 5.76e-178: 547: 28.17
+	Hs
		384781 NTRK1_HUMAN (1-796): 0: 621: 100.00		AP3B2_HUMAN (16-594): 2.55e-174: 537: 28.71
+	Hs
		212583 NTRK1_HUMAN (1-796): 0: 621: 100.00		AP1G1_HUMAN (11-808): 1.03e-173: 527: 17.57
+	Rn
		102587 INSR_RAT (493-777): 7.31e-66: 241: 41.95		G3V9N8_RAT (1-937): 0: 876: 84.08
+	Hs
		321487 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Hs
		507921 FGFR1_HUMAN (195-794): 0: 545: 26.34		COPB_HUMAN (8-927): 0: 561: 12.47
+	Hs
		863239 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		COPB_HUMAN (8-927): 0: 561: 12.47
+	Hs
		411342 INSR_HUMAN (493-777): 3e-68: 248: 42.62		COPB_HUMAN (8-927): 0: 561: 12.47
+	Rn
		544774 INSR_RAT (493-777): 7.31e-66: 241: 41.95		COPB_RAT (8-927): 0: 559: 12.47
+	Hs
		863206 ROR2_HUMAN (515-783): 2.79e-66: 239: 43.91		COPB_HUMAN (8-927): 0: 561: 12.47
+	Hs
		863371 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		COPB_HUMAN (8-927): 0: 561: 12.47
+	Rn
		71352 INSR_RAT (493-777): 7.31e-66: 241: 41.95		B2RYN6_RAT (11-808): 9.07e-174: 527: 17.45
+	At
		1352915 BRL2_ARATH (140-396): 2.09e-17: 89.3: 10.49		COPB2_ARATH (6-919): 0: 563: 13.63