HitPredict

Interactor 1: CRYAB (P02511)
Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)
Gene: CRYAB

Interactor 2: DESM (P17661)
Desmin
Gene: DES

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	17590381
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006936 - muscle contraction GO:0030018 - Z disc GO:0070062 - extracellular exosome and 1 others more... GO:0097512 - cardiac myofibril
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 175 Hs			1 470
+	Hs
		415286 HSPB1_HUMAN (7-174): 5.22e-52: 166: 41.08		VIME_HUMAN (28-469): 1.75e-150: 438: 62.19
+	Hs
		384621 CRYAB_HUMAN (1-175): 1.13e-65: 200: 100.00		GFAP_HUMAN (89-470): 3.63e-131: 387: 61.62
+	Hs
		384376 CRYAA_HUMAN (1-172): 1.51e-54: 172: 51.98		PERI_HUMAN (12-470): 2.14e-134: 397: 59.14
+	Mm
		628519 HSPB2_MOUSE (15-149): 4.39e-37: 127: 42.22		VIME_MOUSE (24-469): 7.89e-147: 429: 61.42
+	Hs
		415332 HSPB1_HUMAN (7-174): 5.22e-52: 166: 41.08		DESM_HUMAN (1-470): 9.86e-110: 334: 100.00
+	Hs
		384608 CRYAB_HUMAN (1-175): 1.13e-65: 200: 100.00		NFL_HUMAN (87-418): 9.8e-89: 282: 53.89
+	Hs
		384412 CRYAA_HUMAN (1-172): 1.51e-54: 172: 51.98		KRT81_HUMAN (1-416): 8.41e-96: 299: 30.95
+	Hs
		415577 HSPB1_HUMAN (7-174): 5.22e-52: 166: 41.08		K2C72_HUMAN (16-419): 7.39e-80: 258: 30.32
+	Hs
		451150 HSPB3_HUMAN (49-154): 2.2e-31: 112: 30.19		NFL_HUMAN (87-418): 9.8e-89: 282: 53.89