HitPredict

Interactor 1: HSP22 (P02515)
Heat shock protein 22
Gene: HSP22

Interactor 2: HSP27 (P02518)
Heat shock protein 27
Gene: HSP27

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP20~HSP20
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008340 - determination of adult lifespan GO:0009408 - response to heat GO:0042026 - protein refolding and 1 others more... GO:0051082 - unfolded protein binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 174 Dm			1 213
+	Dm
		384791 HSP23_DROME (1-174): 7.38e-52: 165: 34.62		HSP27_DROME (1-213): 1.43e-71: 218: 100.00
+	Dm
		384756 HSP22_DROME (1-174): 1.29e-55: 174: 100.00		HSP26_DROME (1-207): 3.83e-57: 181: 42.45
+	Dm
		384790 HSP23_DROME (1-174): 7.38e-52: 165: 34.62		HSP26_DROME (1-207): 3.83e-57: 181: 42.45
+	Mm
		572870 HSPB1_MOUSE (4-173): 3.04e-48: 157: 26.74		HSPB1_MOUSE (4-202): 1.04e-57: 183: 26.92
+	Dm
		384755 HSP22_DROME (1-174): 1.29e-55: 174: 100.00		HSP23_DROME (33-207): 4.08e-51: 165: 47.51
+	Rn
		844291 HSPB1_RAT (4-170): 1.64e-46: 152: 26.63		HSPB1_RAT (4-200): 1.32e-58: 185: 28.16
+	Hs
		415264 HSPB1_HUMAN (4-173): 8.15e-45: 148: 25.58		HSPB1_HUMAN (4-198): 7.4e-59: 185: 27.78
+	Dm
		384796 HSP23_DROME (1-174): 7.38e-52: 165: 34.62		HSP6C_DROME (1-210): 9.07e-50: 162: 33.96
+	Rn
		663485 HSPB1_RAT (4-170): 1.64e-46: 152: 26.63		CRYAB_RAT (13-184): 2.76e-47: 155: 31.98
+	Hs
		384353 HSPB1_HUMAN (4-173): 8.15e-45: 148: 25.58		CRYAA_HUMAN (16-194): 4.22e-48: 157: 25.97
+	Hs
		384350 CRYAA_HUMAN (8-165): 1.05e-44: 147: 23.13		CRYAA_HUMAN (16-194): 4.22e-48: 157: 25.97
+	Hs
		384604 HSPB1_HUMAN (4-173): 8.15e-45: 148: 25.58		CRYAB_HUMAN (13-184): 6.23e-47: 154: 31.98
+	Hs
		384351 CRYAA_HUMAN (8-165): 1.05e-44: 147: 23.13		CRYAB_HUMAN (13-184): 6.23e-47: 154: 31.98
+	Dm
		384754 HSP22_DROME (1-174): 1.29e-55: 174: 100.00		HSP22_DROME (31-198): 1.99e-35: 124: 35.09
+	Hs
		156385 HSPB1_HUMAN (4-173): 8.15e-45: 148: 25.58		HSPB6_HUMAN (1-160): 1.13e-41: 140: 30.00
+	Hs
		415924 HSPB1_HUMAN (4-173): 8.15e-45: 148: 25.58		HSPB8_HUMAN (4-167): 2.22e-38: 133: 27.84
+	Hs
		415596 HSPB1_HUMAN (4-173): 8.15e-45: 148: 25.58		HSPB2_HUMAN (4-164): 1.94e-37: 130: 27.95
+	Hs
		384421 CRYAA_HUMAN (8-165): 1.05e-44: 147: 23.13		HSPB2_HUMAN (4-164): 1.94e-37: 130: 27.95