HitPredict

Interactor 1: PLF4 (P02776)
Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form (Endothelial cell growth inhibitor)]
Gene: PF4

Interactor 2: CCL17 (Q92583)
C-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine)
Gene: CCL17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28381538
Identification Methods	surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006954 - inflammatory response GO:0008009 - chemokine activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 101 Hs			1 94
+	Hs
		390372 PLF4_HUMAN (1-101): 2.42e-32: 110: 100.00		CCL13_HUMAN (6-94): 5.71e-34: 113: 29.21
+	Hs
		390356 PLF4_HUMAN (1-101): 2.42e-32: 110: 100.00		CCL2_HUMAN (15-94): 6.76e-29: 101: 23.46
+	Hs
		390364 PLF4_HUMAN (1-101): 2.42e-32: 110: 100.00		CCL11_HUMAN (16-94): 4.18e-27: 96.6: 30.00
+	Hs
		626429 CXCL2_HUMAN (30-101): 1.8e-28: 100: 41.67		CCL8_HUMAN (15-94): 8.2e-31: 106: 23.46
+	Hs
		190732 PLF4_HUMAN (1-101): 2.42e-32: 110: 100.00		CCL25_HUMAN (4-93): 4.26e-25: 93.1: 23.96
+	Hs
		390357 PLF4_HUMAN (1-101): 2.42e-32: 110: 100.00		CCL5_HUMAN (14-90): 3.39e-25: 91.6: 25.97
+	Hs
		390377 PLF4_HUMAN (1-101): 2.42e-32: 110: 100.00		CCL26_HUMAN (22-93): 3.76e-25: 91.6: 27.78
+	Hs
		843120 CXCL5_HUMAN (21-100): 1.56e-29: 103: 41.25		CCL11_HUMAN (16-94): 4.18e-27: 96.6: 30.00
+	Hs
		390376 PLF4_HUMAN (1-101): 2.42e-32: 110: 100.00		XCL2_HUMAN (4-94): 7.22e-23: 86.6: 23.91
+	Hs
		626428 CXCL2_HUMAN (30-101): 1.8e-28: 100: 41.67		CCL11_HUMAN (16-94): 4.18e-27: 96.6: 30.00
+	Hs
		390361 PLF4_HUMAN (1-101): 2.42e-32: 110: 100.00		XCL1_HUMAN (4-94): 8.79e-23: 86.2: 22.83
+	Hs
		562867 CXCL2_HUMAN (30-101): 1.8e-28: 100: 41.67		CCL5_HUMAN (14-90): 3.39e-25: 91.6: 25.97
+	Hs
		390365 PLF4_HUMAN (1-101): 2.42e-32: 110: 100.00		CCL20_HUMAN (8-94): 1.5e-20: 80: 22.47
+	Hs
		843132 CXCL5_HUMAN (21-100): 1.56e-29: 103: 41.25		XCL2_HUMAN (4-94): 7.22e-23: 86.6: 23.91
+	Hs
		626437 CXCL2_HUMAN (30-101): 1.8e-28: 100: 41.67		XCL2_HUMAN (4-94): 7.22e-23: 86.6: 23.91
+	Hs
		626425 CXCL2_HUMAN (30-101): 1.8e-28: 100: 41.67		XCL1_HUMAN (4-94): 8.79e-23: 86.2: 22.83
+	Hs
		141739 PLF4_HUMAN (1-101): 2.42e-32: 110: 100.00		CCL21_HUMAN (30-93): 4.86e-18: 74.6: 25.00
+	Hs
		843121 CXCL5_HUMAN (21-100): 1.56e-29: 103: 41.25		CCL20_HUMAN (8-94): 1.5e-20: 80: 22.47
+	Hs
		141738 CXCL7_HUMAN (26-99): 4.04e-28: 100: 50.00		CCL21_HUMAN (30-93): 4.86e-18: 74.6: 25.00
+	Hs
		141745 CXCL2_HUMAN (30-101): 1.8e-28: 100: 41.67		CCL21_HUMAN (30-93): 4.86e-18: 74.6: 25.00