HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: HECD3 (Q5T447)
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)
Gene: HECTD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.50	0.512

Property	Details
Experiments	28636940
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 648 Hs			1 861
+	Hs
		401310 RAF1_HUMAN (1-648): 0: 637: 100.00		ITCH_HUMAN (337-855): 6.29e-174: 528: 18.22
+	Hs
		400458 RAF1_HUMAN (1-648): 0: 637: 100.00		NEDD4_HUMAN (374-853): 2.31e-168: 525: 20.53
+	Hs
		131652 RAF1_HUMAN (1-648): 0: 637: 100.00		WWP2_HUMAN (355-855): 2.68e-169: 514: 18.43
+	Hs
		401325 RAF1_HUMAN (1-648): 0: 637: 100.00		NED4L_HUMAN (374-853): 5.34e-166: 509: 19.11
+	Mm
		1298421 RAF1_MOUSE (1-648): 0: 632: 97.69		NED4L_MOUSE (374-853): 6.91e-166: 510: 19.31
+	Hs
		401060 RAF1_HUMAN (1-648): 0: 637: 100.00		HUWE1_HUMAN (327-854): 2.82e-151: 494: 19.37
+	Hs
		578547 BRAF_HUMAN (39-647): 9.6e-166: 494: 56.02		SMUF2_HUMAN (337-855): 4.37e-178: 533: 19.82
+	Hs
		578533 BRAF_HUMAN (39-647): 9.6e-166: 494: 56.02		ITCH_HUMAN (337-855): 6.29e-174: 528: 18.22
+	Hs
		521411 ARAF_HUMAN (44-646): 8.15e-165: 486: 59.18		ITCH_HUMAN (337-855): 6.29e-174: 528: 18.22
+	Hs
		131711 BRAF_HUMAN (39-647): 9.6e-166: 494: 56.02		WWP2_HUMAN (355-855): 2.68e-169: 514: 18.43
+	Hs
		578542 BRAF_HUMAN (39-647): 9.6e-166: 494: 56.02		WWP1_HUMAN (355-855): 1.14e-168: 514: 18.51
+	Hs
		578534 BRAF_HUMAN (39-647): 9.6e-166: 494: 56.02		NED4L_HUMAN (374-853): 5.34e-166: 509: 19.11
+	Hs
		1309235 KSR1_HUMAN (138-648): 4.19e-108: 349: 24.61		ITCH_HUMAN (337-855): 6.29e-174: 528: 18.22
+	Hs
		557168 SRC_HUMAN (331-607): 2.21e-106: 334: 33.45		NEDD4_HUMAN (374-853): 2.31e-168: 525: 20.53
+	Hs
		463017 YES_HUMAN (329-607): 9.75e-106: 332: 33.92		NEDD4_HUMAN (374-853): 2.31e-168: 525: 20.53
+	Hs
		400889 RAF1_HUMAN (1-648): 0: 637: 100.00		HERC1_HUMAN (517-855): 4e-53: 204: 36.72
+	Hs
		342718 RAF1_HUMAN (1-648): 0: 637: 100.00		HERC2_HUMAN (237-368): 1.38e-43: 174: 36.84
+	Hs
		342734 BRAF_HUMAN (39-647): 9.6e-166: 494: 56.02		HERC2_HUMAN (237-368): 1.38e-43: 174: 36.84
+	Hs
		342726 ARAF_HUMAN (44-646): 8.15e-165: 486: 59.18		HERC2_HUMAN (237-368): 1.38e-43: 174: 36.84
+	Hs
		557371 SRC_HUMAN (331-607): 2.21e-106: 334: 33.45		CUL9_HUMAN (245-370): 1.19e-18: 94: 40.63