HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 780
+	Hs
		411278 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		411297 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62
+	Hs
		435618 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Hs
		411311 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Rn
		783510 T2CB11_RAT (1-1382): 0: 1538: 94.87		PTN11_RAT (7-351): 1.11e-123: 385: 31.48
+	Hs
		411291 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		411363 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		411290 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTN2_HUMAN (24-401): 2.72e-123: 377: 23.85
+	Hs
		435549 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Hs
		411394 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTPRK_HUMAN (17-297): 1.82e-59: 221: 26.64
+	Hs
		435529 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		435620 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		411298 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50
+	Hs
		411401 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTPRO_HUMAN (58-303): 3.31e-46: 180: 38.71
+	Hs
		411369 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Hs
		537715 INSRR_HUMAN (13-1341): 0: 1293: 51.12		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		435558 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PTN7_HUMAN (58-298): 7.19e-43: 161: 38.93
+	Dm
		448231 INSR_DROME (30-1382): 0: 1002: 34.55		LAR_DROME (8-302): 1.8e-92: 319: 30.33
+	Dm
		448233 INSR_DROME (30-1382): 0: 1002: 34.55		PTP99_DROME (10-319): 2.98e-44: 174: 21.07
+	Hs
		872635 EPHA4_HUMAN (562-1354): 0: 565: 20.36		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48