HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: CSKI2 (Q8WXE0)
Caskin-2 (CASK-interacting protein 2)
Gene: CASKIN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SAM_1, SH2~SH3_2, Ank_2~SH3_1, SH3_1~SH3_2
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 1202
+	Hs
		433924 LYN_HUMAN (1-509): 0: 582: 62.72		CSKI2_HUMAN (1-1202): 1.75e-114: 387: 100.00
+	Hs
		411885 LCK_HUMAN (1-509): 0: 661: 100.00		KDIS_HUMAN (1-302): 1.57e-71: 265: 22.91
+	Hs
		434071 LYN_HUMAN (1-509): 0: 582: 62.72		KDIS_HUMAN (1-302): 1.57e-71: 265: 22.91
+	Hs
		434072 LYN_HUMAN (1-509): 0: 582: 62.72		ANR50_HUMAN (63-902): 1.51e-56: 217: 13.49
+	Hs
		337406 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		DAPK1_HUMAN (6-585): 7.81e-75: 274: 15.56
+	Dm
		337696 SRC64_DROME (39-507): 7.74e-179: 515: 46.33		TNKS_DROME (2-711): 1.95e-65: 244: 13.41
+	Hs
		297808 LYN_HUMAN (1-509): 0: 582: 62.72		K0754_HUMAN (628-980): 4.7e-43: 174: 17.38
+	Hs
		411697 LCK_HUMAN (1-509): 0: 661: 100.00		ANK3_HUMAN (56-264): 1.05e-09: 65.5: 28.23
+	Hs
		433730 LYN_HUMAN (1-509): 0: 582: 62.72		ANK3_HUMAN (56-264): 1.05e-09: 65.5: 28.23
+	Hs
		433701 LYN_HUMAN (1-509): 0: 582: 62.72		ANK2_HUMAN (315-1185): 2.96e-09: 63.9: 11.00
+	Ce
		220231 SRC2_CAEEL (35-507): 0: 526: 47.71		Q93203_CAEEL (4-289): 7.47e-26: 117: 29.55