HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: DLG5 (Q8TDM6)
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)
Gene: DLG5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0008285 - negative regulation of cell population proliferation GO:0051965 - positive regulation of synapse assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 1919
+	Hs
		541606 FGFR1_HUMAN (195-794): 0: 544: 26.34		DLG5_HUMAN (1-1919): 0: 879: 100.00
+	Hs
		1159518 NTRK2_HUMAN (12-796): 1.39e-176: 529: 47.08		DLG5_HUMAN (1-1919): 0: 879: 100.00
+	Hs
		648600 FGFR4_HUMAN (140-795): 1.88e-172: 518: 26.47		DLG5_HUMAN (1-1919): 0: 879: 100.00
+	Hs
		641219 FGFR2_HUMAN (71-794): 1.05e-156: 478: 22.21		DLG5_HUMAN (1-1919): 0: 879: 100.00
+	Hs
		411836 NTRK1_HUMAN (1-796): 0: 624: 100.00		DLG1_HUMAN (1122-1916): 1.67e-154: 501: 20.14
+	Hs
		1034298 ROR2_HUMAN (515-783): 2.81e-66: 239: 43.91		DLG5_HUMAN (1-1919): 0: 879: 100.00
+	Hs
		1351403 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		DLG5_HUMAN (1-1919): 0: 879: 100.00
+	Hs
		1091505 NTRK3_HUMAN (36-796): 2.7e-175: 527: 49.37		DLG1_HUMAN (1122-1916): 1.67e-154: 501: 20.14
+	Hs
		1006074 NTRK2_HUMAN (12-796): 1.39e-176: 529: 47.08		DLG4_HUMAN (1177-1916): 8.05e-155: 496: 19.44
+	Mm
		581992 NTRK2_MOUSE (12-796): 1.1e-175: 527: 48.05		DLG4_MOUSE (1177-1916): 1.49e-154: 495: 19.44
+	Hs
		412720 NTRK1_HUMAN (1-796): 0: 624: 100.00		PALS2_HUMAN (1396-1919): 2.59e-106: 353: 14.80
+	Hs
		931842 EPHA5_HUMAN (409-788): 2.23e-111: 365: 30.36		DLG1_HUMAN (1122-1916): 1.67e-154: 501: 20.14
+	Hs
		650293 FGFR3_HUMAN (168-794): 3.36e-157: 479: 25.83		PALS1_HUMAN (1500-1916): 1.31e-98: 336: 18.78
+	Hs
		1091597 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		DLG1_HUMAN (1122-1916): 1.67e-154: 501: 20.14
+	Hs
		1006121 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		DLG4_HUMAN (1177-1916): 8.05e-155: 496: 19.44
+	Hs
		411796 NTRK1_HUMAN (1-796): 0: 624: 100.00		ZO1_HUMAN (698-816): 5.89e-09: 63.8: 16.81
+	Hs
		541539 FGFR1_HUMAN (195-794): 0: 544: 26.34		MPP7_HUMAN (1327-1437): 1.62e-09: 64.7: 23.89
+	Hs
		1156968 NTRK3_HUMAN (36-796): 2.7e-175: 527: 49.37		MPP7_HUMAN (1327-1437): 1.62e-09: 64.7: 23.89
+	Rn
		92830 INSR_RAT (493-777): 7.34e-66: 241: 41.95		MPP2_RAT (1396-1919): 8.91e-102: 340: 13.50
+	Hs
		1058958 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		ZO1_HUMAN (698-816): 5.89e-09: 63.8: 16.81