HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23131831
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0045087 - innate immune response GO:0046872 - metal ion binding GO:0050852 - T cell receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Hs			1 419
+	Hs
		523232 SRC_HUMAN (1-537): 0: 598: 68.21		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		454851 FGR_HUMAN (1-536): 0: 581: 69.82		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		411983 FYN_HUMAN (1-537): 0: 643: 100.00		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		411910 LCK_HUMAN (40-535): 0: 551: 57.60		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		434106 LYN_HUMAN (1-535): 0: 535: 54.48		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		412058 FYN_HUMAN (1-537): 0: 643: 100.00		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		412287 FYN_HUMAN (1-537): 0: 643: 100.00		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89
+	Hs
		433781 LYN_HUMAN (1-535): 0: 535: 54.48		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		411905 LCK_HUMAN (40-535): 0: 551: 57.60		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Hs
		111443 J3QRU1_HUMAN (1-537): 0: 591: 71.61		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		433272 YES_HUMAN (1-537): 0: 591: 71.61		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		523231 SRC_HUMAN (1-537): 0: 598: 68.21		MYH4_HUMAN (21-393): 8.88e-09: 60: 13.44
+	Hs
		411581 LCK_HUMAN (40-535): 0: 551: 57.60		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		433558 LYN_HUMAN (1-535): 0: 535: 54.48		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		411758 LCK_HUMAN (40-535): 0: 551: 57.60		MRCKA_HUMAN (32-363): 1.19e-13: 75.1: 15.89
+	Hs
		411908 LCK_HUMAN (40-535): 0: 551: 57.60		MRCKB_HUMAN (39-356): 2.85e-10: 64.7: 13.60
+	Hs
		433818 LYN_HUMAN (1-535): 0: 535: 54.48		MRCKA_HUMAN (32-363): 1.19e-13: 75.1: 15.89
+	Hs
		433620 LYN_HUMAN (1-535): 0: 535: 54.48		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		434101 LYN_HUMAN (1-535): 0: 535: 54.48		MRCKB_HUMAN (39-356): 2.85e-10: 64.7: 13.60
+	Hs
		724720 BLK_HUMAN (28-532): 2.42e-179: 515: 56.72		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93