HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: TONSL (Q96HA7)
Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)
Gene: TONSL

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_6~LRR_8
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 1378
+	Hs
		412577 NTRK1_HUMAN (1-796): 0: 624: 100.00		TANC1_HUMAN (72-671): 1.77e-74: 276: 13.90
+	Hs
		541675 FGFR1_HUMAN (195-794): 0: 544: 26.34		TANC1_HUMAN (72-671): 1.77e-74: 276: 13.90
+	Hs
		177161 NTRK1_HUMAN (1-796): 0: 624: 100.00		ANR28_HUMAN (88-660): 2.17e-46: 184: 12.97
+	Hs
		411756 NTRK1_HUMAN (1-796): 0: 624: 100.00		ANK2_HUMAN (468-781): 1.15e-43: 177: 16.10
+	Hs
		648659 FGFR4_HUMAN (140-795): 1.88e-172: 518: 26.47		TANC1_HUMAN (72-671): 1.77e-74: 276: 13.90
+	Hs
		274075 NTRK1_HUMAN (1-796): 0: 624: 100.00		ANR17_HUMAN (199-583): 1.92e-33: 143: 16.03
+	Hs
		412260 NTRK1_HUMAN (1-796): 0: 624: 100.00		ANR44_HUMAN (71-601): 6.36e-31: 134: 11.58
+	Hs
		412208 NTRK1_HUMAN (1-796): 0: 624: 100.00		GPSM1_HUMAN (2-219): 3.25e-31: 133: 16.51
+	Hs
		412407 NTRK1_HUMAN (1-796): 0: 624: 100.00		TTC28_HUMAN (2-239): 3.27e-24: 113: 17.28
+	Hs
		185345 NTRK1_HUMAN (1-796): 0: 624: 100.00		OGT1_HUMAN (90-425): 1.51e-22: 107: 17.56
+	Hs
		411277 NTRK1_HUMAN (1-796): 0: 624: 100.00		RINI_HUMAN (1008-1220): 1.84e-21: 101: 17.76
+	Hs
		541458 FGFR1_HUMAN (195-794): 0: 544: 26.34		ANK3_HUMAN (468-830): 2.25e-44: 179: 16.02
+	Hs
		541441 FGFR1_HUMAN (195-794): 0: 544: 26.34		ANK2_HUMAN (468-781): 1.15e-43: 177: 16.10
+	Hs
		1091406 NTRK3_HUMAN (36-796): 2.7e-175: 527: 49.37		ANK3_HUMAN (468-830): 2.25e-44: 179: 16.02
+	Hs
		506922 FGFR3_HUMAN (168-794): 3.36e-157: 479: 25.83		POTEI_HUMAN (420-1042): 3.9e-54: 209: 12.31
+	Hs
		541315 FGFR1_HUMAN (195-794): 0: 544: 26.34		ANK1_HUMAN (518-835): 2.72e-31: 136: 16.11
+	Hs
		648576 FGFR4_HUMAN (140-795): 1.88e-172: 518: 26.47		GPSM1_HUMAN (2-219): 3.25e-31: 133: 16.51
+	Hs
		463950 RET_HUMAN (391-794): 4.65e-114: 374: 30.44		ANK3_HUMAN (468-830): 2.25e-44: 179: 16.02
+	At
		1441449 TMK3_ARATH (60-784): 2.91e-145: 452: 19.98		RGI1_ARATH (755-1180): 1.88e-14: 81: 12.65
+	Hs
		439627 INSR_HUMAN (493-777): 3.01e-68: 248: 42.62		POTEJ_HUMAN (405-1042): 4.02e-54: 208: 12.33