HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: CDN2B (P42772)
Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)
Gene: CDKN2B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~P53, Ank_2~P53_tetramer
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0008285 - negative regulation of cell population proliferation and 1 others more... GO:0090398 - cellular senescence
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 138
+	Hs
		413355 P53_HUMAN (1-393): 0: 619: 100.00		CDN2A_HUMAN (9-137): 9.38e-55: 170: 81.96
+	Hs
		413357 P53_HUMAN (1-393): 0: 619: 100.00		CDN2C_HUMAN (18-137): 2.42e-39: 131: 44.17
+	Hs
		414862 P53_HUMAN (1-393): 0: 619: 100.00		ANR26_HUMAN (18-138): 1.05e-32: 122: 23.58
+	Hs
		413730 P53_HUMAN (1-393): 0: 619: 100.00		ANK3_HUMAN (51-138): 6.74e-23: 95: 20.46
+	Hs
		413461 P53_HUMAN (1-393): 0: 619: 100.00		DAPK1_HUMAN (1-99): 3.66e-20: 87: 19.00
+	Hs
		413644 P53_HUMAN (1-393): 0: 619: 100.00		ANK2_HUMAN (1-65): 6.64e-17: 77.7: 22.73
+	Hs
		295443 P53_HUMAN (1-393): 0: 619: 100.00		PSD10_HUMAN (53-137): 2.57e-17: 76.5: 15.29
+	Mm
		382527 P53_MOUSE (1-393): 0: 589: 77.35		PSD10_MOUSE (53-137): 2.59e-17: 76.5: 15.29
+	Mm
		382499 P53_MOUSE (1-393): 0: 589: 77.35		DAPK1_MOUSE (51-138): 3.55e-12: 64.2: 19.51
+	Hs
		842861 P63_HUMAN (28-363): 2.36e-145: 429: 42.11		CDN2A_HUMAN (9-137): 9.38e-55: 170: 81.96