HitPredict - High confidence protein-protein interactions

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: BAX (Q07812)
Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)
Gene: BAX

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	25115399, 32064756
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Bcl-2~P53
Common GO terms	GO:0001836 - release of cytochrome c from mitochondria GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005783 - endoplasmic reticulum and 16 others more... GO:0005829 - cytosol GO:0009651 - response to salt stress GO:0010332 - response to gamma radiation GO:0034644 - cellular response to UV GO:0042981 - regulation of apoptotic process GO:0043065 - positive regulation of apoptotic process GO:0043525 - positive regulation of neuron apoptotic process GO:0046982 - protein heterodimerization activity GO:0048147 - negative regulation of fibroblast proliferation GO:0051726 - regulation of cell cycle GO:0070059 - intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070242 - thymocyte apoptotic process GO:0072332 - intrinsic apoptotic signaling pathway by p53 class mediator GO:0090200 - positive regulation of release of cytochrome c from mitochondria GO:0097193 - intrinsic apoptotic signaling pathway GO:2001244 - positive regulation of intrinsic apoptotic signaling pathway
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	393
Hs

1	192

Service provided by Combinatics, Japan

Last updated: 11Aug2025