HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: VRK2 (Q86Y07)
Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2)
Gene: VRK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	16704422
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0006974 - DNA damage response GO:0032991 - protein-containing complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 508
+	Hs
		414504 P53_HUMAN (1-393): 0: 619: 100.00		VRK1_HUMAN (4-383): 2.82e-130: 386: 47.66
+	Hs
		413399 P53_HUMAN (1-393): 0: 619: 100.00		KC1D_HUMAN (21-462): 2.39e-111: 338: 23.60
+	Hs
		413398 P53_HUMAN (1-393): 0: 619: 100.00		KC1A_HUMAN (17-366): 7.17e-107: 323: 24.72
+	Hs
		414938 P53_HUMAN (1-393): 0: 619: 100.00		KC1G3_HUMAN (24-448): 3.56e-105: 323: 21.91
+	Hs
		414211 P53_HUMAN (1-393): 0: 619: 100.00		KC1AL_HUMAN (17-366): 7.29e-103: 313: 24.15
+	Hs
		413886 P53_HUMAN (1-393): 0: 619: 100.00		KS6A1_HUMAN (5-369): 1.86e-84: 277: 11.47
+	Hs
		413448 P53_HUMAN (1-393): 0: 619: 100.00		KS6A3_HUMAN (12-314): 9.68e-83: 273: 10.93
+	Hs
		413881 P53_HUMAN (1-393): 0: 619: 100.00		KS6A2_HUMAN (3-329): 2.78e-82: 271: 11.87
+	Hs
		414150 P53_HUMAN (1-393): 0: 619: 100.00		VRK3_HUMAN (15-322): 1.62e-53: 189: 36.45