HitPredict

Interactor 1: CALM (P06787)
Calmodulin (CaM)
Gene: CMD1

Interactor 2: MYO3 (P36006)
Myosin-3 (Actin-dependent myosin-I MYO3) (Class I unconventional myosin MYO3) (Type I myosin MYO3)
Gene: MYO3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.890

Property	Details
Experiments	11805837, 16554755, 30635263, 16429126
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, two hybrid, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	EF-hand_7~Myosin_head, EF-hand_7~Myosin_TH1
Common GO terms	GO:0006897 - endocytosis GO:0030050 - vesicle transport along actin filament GO:0030479 - actin cortical patch GO:0045160 - myosin I complex GO:2000601 - positive regulation of Arp2/3 complex-mediated actin nucleation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Sc			1 1272
+	Sc
		420336 CALM_YEAST (1-147): 4.58e-47: 151: 100.00		MYO5_YEAST (1-1221): 0: 1079: 72.81
+	Sc
		420223 CALM_YEAST (1-147): 4.58e-47: 151: 100.00		MYO2_YEAST (6-979): 0: 1026: 28.98
+	Hs
		483923 CALM1_HUMAN (80-147): 4.86e-12: 61.3: 40.58		MYO1E_HUMAN (24-1180): 0: 1058: 37.03
+	Hs
		483998 CALM2_HUMAN (80-147): 4.86e-12: 61.3: 40.58		MYO1E_HUMAN (24-1180): 0: 1058: 37.03
+	Hs
		484116 CALM3_HUMAN (80-147): 4.86e-12: 61.3: 40.58		MYO1E_HUMAN (24-1180): 0: 1058: 37.03
+	Hs
		484202 CALM3_HUMAN (80-147): 4.86e-12: 61.3: 40.58		MYO10_HUMAN (18-1071): 0: 1055: 26.72
+	Hs
		484218 CALM3_HUMAN (80-147): 4.86e-12: 61.3: 40.58		MYO5B_HUMAN (9-1146): 0: 1043: 25.02
+	Sp
		409421 CALM_SCHPO (73-147): 2.57e-11: 59.4: 35.53		MYO1_SCHPO (24-1223): 0: 1039: 51.12
+	Dm
		906697 CALM_DROME (80-147): 7.11e-12: 61: 40.58		MYO7A_DROME (2-1088): 0: 1027: 27.43
+	Hs
		117566 CALM1_HUMAN (80-147): 4.86e-12: 61.3: 40.58		MYO1C_HUMAN (33-758): 0: 572: 41.49
+	Hs
		117567 CALM2_HUMAN (80-147): 4.86e-12: 61.3: 40.58		MYO1C_HUMAN (33-758): 0: 572: 41.49
+	Hs
		117568 CALM3_HUMAN (80-147): 4.86e-12: 61.3: 40.58		MYO1C_HUMAN (33-758): 0: 572: 41.49
+	Dm
		906666 CALM_DROME (80-147): 7.11e-12: 61: 40.58		MY61F_DROME (31-794): 0: 572: 42.02
+	Hs
		117594 CALL3_HUMAN (85-147): 4.31e-11: 59: 40.63		MYO1C_HUMAN (33-758): 0: 572: 41.49
+	Hs
		214479 CALM1_HUMAN (80-147): 4.86e-12: 61.3: 40.58		MYO1B_HUMAN (36-730): 5.18e-167: 529: 39.80
+	Hs
		214480 CALM3_HUMAN (80-147): 4.86e-12: 61.3: 40.58		MYO1B_HUMAN (36-730): 5.18e-167: 529: 39.80
+	Hs
		111438 CALM3_HUMAN (80-147): 4.86e-12: 61.3: 40.58		J3QRN6_HUMAN (35-751): 1.34e-167: 525: 40.21
+	Hs
		297277 CALM1_HUMAN (80-147): 4.86e-12: 61.3: 40.58		MYO1D_HUMAN (35-751): 7.05e-167: 525: 40.21
+	Hs
		297278 CALM2_HUMAN (80-147): 4.86e-12: 61.3: 40.58		MYO1D_HUMAN (35-751): 7.05e-167: 525: 40.21
+	Hs
		484046 CALM2_HUMAN (80-147): 4.86e-12: 61.3: 40.58		MYO1A_HUMAN (36-730): 2.22e-160: 509: 39.61