HitPredict

Interactor 1: IGF1 (P05019)
Insulin-like growth factor 1 (Insulin-like growth factor I) (IGF-I) (Mechano growth factor) (MGF) (Somatomedin-C)
Gene: IGF1

Interactor 2: IBP3 (P17936)
Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)
Gene: IGFBP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.963

The method score is based on:

Property Details
Experiments 12735930, 10823924, 9497324, 11600567, 1383255, 9446566, 22578544
Identification Methods pull down, affinity chromatography technology, bio-layer interferometry
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains IGFBP~Insulin, Insulin~Thyroglobulin_1
Common GO terms GO:0001649 - osteoblast differentiation
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0008285 - negative regulation of cell population proliferation
GO:0016942 - insulin-like growth factor binding protein complex
and 4 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 195
Hs

1 291
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Service provided by Combinatics, Japan

Last updated: 11Aug2025