HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: FGR (P09769)
Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)
Gene: FGR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.672

Property	Details
Experiments	22939624, 31980649, 8043579, unassigned2173
Identification Methods	affinity chromatography technology, biophysical, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005576 - extracellular region GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0034774 - secretory granule lumen and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 529
+	Hs
		411945 HS90A_HUMAN (1-732): 0: 1087: 100.00		FYN_HUMAN (1-527): 0: 607: 69.94
+	Hs
		431481 HS90A_HUMAN (1-732): 0: 1087: 100.00		SRC_HUMAN (1-527): 0: 602: 65.74
+	Hs
		431433 HS90A_HUMAN (1-732): 0: 1087: 100.00		YES_HUMAN (1-527): 0: 596: 67.83
+	Hs
		411949 HS90B_HUMAN (19-732): 0: 1059: 86.13		FYN_HUMAN (1-527): 0: 607: 69.94
+	Hs
		431445 HS90A_HUMAN (1-732): 0: 1087: 100.00		HCK_HUMAN (1-524): 0: 568: 56.30
+	Hs
		411551 HS90A_HUMAN (1-732): 0: 1087: 100.00		LCK_HUMAN (1-526): 0: 559: 51.90
+	Rn
		948934 HS90A_RAT (1-732): 0: 1085: 97.95		LYN_RAT (1-524): 0: 556: 54.29
+	Hs
		431434 HS90A_HUMAN (1-732): 0: 1087: 100.00		LYN_HUMAN (1-524): 0: 553: 53.91
+	Hs
		431666 HS90A_HUMAN (1-732): 0: 1087: 100.00		BLK_HUMAN (1-524): 0: 532: 54.10
+	Hs
		411556 HS90B_HUMAN (19-732): 0: 1059: 86.13		LCK_HUMAN (1-526): 0: 559: 51.90
+	Hs
		337312 HS90A_HUMAN (1-732): 0: 1087: 100.00		ABL1_HUMAN (45-524): 3.04e-174: 523: 41.10
+	Hs
		431626 HS90A_HUMAN (1-732): 0: 1087: 100.00		ABL2_HUMAN (7-524): 3.9e-173: 521: 38.64
+	Hs
		431627 HS90A_HUMAN (1-732): 0: 1087: 100.00		FRK_HUMAN (72-521): 3.42e-179: 515: 51.83
+	Hs
		431927 HS90A_HUMAN (1-732): 0: 1087: 100.00		Q573B4_HUMAN (21-526): 3.54e-174: 502: 49.80
+	Hs
		337314 HS90B_HUMAN (19-732): 0: 1059: 86.13		ABL1_HUMAN (45-524): 3.04e-174: 523: 41.10
+	Hs
		431782 HS90A_HUMAN (1-732): 0: 1087: 100.00		ITK_HUMAN (42-518): 1.23e-163: 479: 36.14
+	Hs
		431769 HS90A_HUMAN (1-732): 0: 1087: 100.00		BTK_HUMAN (21-523): 6.61e-159: 469: 33.01
+	Hs
		432259 HS90A_HUMAN (1-732): 0: 1087: 100.00		SRMS_HUMAN (53-517): 6.24e-159: 463: 41.56
+	Hs
		431838 HS90A_HUMAN (1-732): 0: 1087: 100.00		PTK6_HUMAN (79-521): 1.18e-158: 460: 42.63
+	Hs
		69196 HS90B_HUMAN (19-732): 0: 1059: 86.13		A9UEZ6_HUMAN (109-519): 7.4e-102: 337: 43.75