Protein: IL5RA
Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125)

Gene: IL5RA
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q01344

Gene Ontology (top 5):
GO:0002437 - inflammatory response to antigenic stimulus
GO:0004896 - cytokine receptor activity
GO:0004914 - interleukin-5 receptor activity
GO:0005615 - extracellular space
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

424331

IL5
Interleukin-5

6

1

Small-scale

0.961

High

748679

IL3RB
Cytokine receptor common subunit beta

2

17

Small-scale

0.776

High

1030177

VWA1
von Willebrand factor A domain-containing protein 1

1

1

High-throughput

0.691

High

1030200

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

20

High-throughput

0.691

High

1030150

IL5RA
Interleukin-5 receptor subunit alpha

1

18

Small-scale

0.647

High

140230

SDCB1
Syntenin-1

2

5

Small-scale

0.636

High

253339

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.586

High

62936

POTEF
POTE ankyrin domain family member F

1

5

High-throughput

0.536

High

144052

MA2B1
Lysosomal alpha-mannosidase

1

3

High-throughput

0.536

High

161020

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

6

High-throughput

0.536

High

175357

PLXB2
Plexin-B2

1

12

High-throughput

0.536

High

183241

LAMA5
Laminin subunit alpha-5

1

15

High-throughput

0.536

High

274873

LRP5
Low-density lipoprotein receptor-related protein 5

1

6

High-throughput

0.536

High

287553

LRP6
Low-density lipoprotein receptor-related protein 6

1

6

High-throughput

0.536

High

320870

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

8

High-throughput

0.536

High

338731

NPTXR
Neuronal pentraxin receptor

1

1

High-throughput

0.536

High

350702

NOE2
Noelin-2

1

3

High-throughput

0.536

High

376808

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

3

High-throughput

0.536

High

467826

BGLR
Beta-glucuronidase

1

1

High-throughput

0.536

High

473694

ITA5
Integrin alpha-5

1

2

High-throughput

0.536

High

501812

CO4A
Complement C4-A

1

1

High-throughput

0.536

High

520812

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

4

High-throughput

0.536

High

534945

BIP
Endoplasmic reticulum chaperone BiP

1

13

High-throughput

0.536

High

535834

LAMC1
Laminin subunit gamma-1

1

14

High-throughput

0.536

High

551852

CO6A2

1

2

High-throughput

0.536

High

554212

BMP4
Bone morphogenetic protein 4

1

3

High-throughput

0.536

High

562713

BMP1
Bone morphogenetic protein 1

1

6

High-throughput

0.536

High

566635

PDIA4
Protein disulfide-isomerase A4

1

6

High-throughput

0.536

High

580759

PVR
Poliovirus receptor

1

8

High-throughput

0.536

High

600604

NAGAB
Alpha-N-acetylgalactosaminidase

1

2

High-throughput

0.536

High

618184

AMD
Peptidyl-glycine alpha-amidating monooxygenase

1

1

High-throughput

0.536

High

648486

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.536

High

650131

FGFR3
Fibroblast growth factor receptor 3

1

15

High-throughput

0.536

High

658690

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.536

High

709057

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

20

High-throughput

0.536

High

720409

ACHA5
Neuronal acetylcholine receptor subunit alpha-5

1

1

High-throughput

0.536

High

810598

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

1

High-throughput

0.536

High

876670

HSP13
Heat shock 70 kDa protein 13

1

7

High-throughput

0.536

High

902991

MMP15
Matrix metalloproteinase-15

1

2

High-throughput

0.536

High

907895

PLXA3
Plexin-A3

1

12

High-throughput

0.536

High

1022534

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

10

High-throughput

0.536

High

1030151

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

1

High-throughput

0.536

High

1030152

DSC2
Desmocollin-2

1

20

High-throughput

0.536

High

1030155

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

1

High-throughput

0.536

High

1030157

SEM3B
Semaphorin-3B

1

3

High-throughput

0.536

High

1030161

STIM1
Stromal interaction molecule 1

1

2

High-throughput

0.536

High

1030162

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

2

High-throughput

0.536

High

1030167

SGCB
Beta-sarcoglycan

1

1

High-throughput

0.536

High

1030168

T132A
Transmembrane protein 132A

1

2

High-throughput

0.536

High

1030174

METRL
Meteorin-like protein

1

1

High-throughput

0.536

High

1030175

OLM2A
Olfactomedin-like protein 2A

1

3

High-throughput

0.536

High

1030178

CSPG4
Chondroitin sulfate proteoglycan 4

1

4

High-throughput

0.536

High

1030182

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

12

High-throughput

0.536

High

1030185

ANR46
Ankyrin repeat domain-containing protein 46

1

9

High-throughput

0.536

High

1030186

FRAS1
Extracellular matrix organizing protein FRAS1

1

10

High-throughput

0.536

High

1030189

SULF2
Extracellular sulfatase Sulf-2

1

4

High-throughput

0.536

High

1030191

SUMF1
Formylglycine-generating enzyme

1

1

High-throughput

0.536

High

1030194

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

5

High-throughput

0.536

High

1030196

KREM2
Kremen protein 2

1

3

High-throughput

0.536

High

1030198

TM131
Transmembrane protein 131

1

3

High-throughput

0.536

High

1030199

PXDN
Peroxidasin homolog

1

2

High-throughput

0.536

High

1030202

PCSK5
Proprotein convertase subtilisin/kexin type 5

1

8

High-throughput

0.536

High

1030205

FKB10
Peptidyl-prolyl cis-trans isomerase FKBP10

1

2

High-throughput

0.536

High

1030206

ARSG
Arylsulfatase G

1

4

High-throughput

0.536

High

1030207

I17RA
Interleukin-17 receptor A

1

2

High-throughput

0.536

High

1030209

GDF15
Growth/differentiation factor 15

1

5

High-throughput

0.536

High

1030210

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

3

High-throughput

0.536

High

1030211

CNTP3
Contactin-associated protein-like 3

1

8

High-throughput

0.536

High

1030212

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

3

High-throughput

0.536

High

1030213

CHRD
Chordin

1

8

High-throughput

0.536

High

1030214

SEM6B
Semaphorin-6B

1

3

High-throughput

0.536

High

1030217

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

9

High-throughput

0.536

High

1030219

SEM4G
Semaphorin-4G

1

4

High-throughput

0.536

High

1030225

TEN3
Teneurin-3

1

6

High-throughput

0.536

High

1030228

CEIP2
Cell surface hyaluronidase CEMIP2

1

2

High-throughput

0.536

High

1030229

PLXA1
Plexin-A1

1

11

High-throughput

0.536

High

1030231

ICAM5
Intercellular adhesion molecule 5

1

9

High-throughput

0.536

High

1030233

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.536

High

1030234

AGRG1
Adhesion G-protein coupled receptor G1

1

2

High-throughput

0.536

High

932359

ANAG
Alpha-N-acetylglucosaminidase

1

0

High-throughput

0.513

High

1028100

B4GN1
Beta-1,4 N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.513

High

1030154

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

1

0

High-throughput

0.513

High

1030156

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

1030158

MSLN
Mesothelin

1

0

High-throughput

0.513

High

1030165

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.513

High

1030172

ERFE
Erythroferrone

1

0

High-throughput

0.513

High

1030173

GT253
Inactive glycosyltransferase 25 family member 3

1

0

High-throughput

0.513

High

1030203

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.513

High

1030226

CHPF2
Chondroitin sulfate glucuronyltransferase

1

0

High-throughput

0.513

High

1030159

U119A
Protein unc-119 homolog A

1

1

Small-scale

0.504

High

363142

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.501

High

164733

HS3S1
Heparan sulfate glucosamine 3-O-sulfotransferase 1

1

1

High-throughput

0.489

High

193694

TPSN
Tapasin

1

8

High-throughput

0.489

High

569449

DHB1
17-beta-hydroxysteroid dehydrogenase type 1

1

2

High-throughput

0.489

High

756542

GALNS
N-acetylgalactosamine-6-sulfatase

1

4

High-throughput

0.489

High

885464

MA2A2
Alpha-mannosidase 2x

1

3

High-throughput

0.489

High

907210

SPHM
N-sulphoglucosamine sulphohydrolase

1

4

High-throughput

0.489

High

937385

LAMB2
Laminin subunit beta-2

1

10

High-throughput

0.489

High

1030160

OS9
Protein OS-9

1

1

High-throughput

0.489

High

1030163

LAMB3
Laminin subunit beta-3

1

13

High-throughput

0.489

High

1030164

MBTP1
Membrane-bound transcription factor site-1 protease

1

5

High-throughput

0.489

High

1030176

SCAR3
Scavenger receptor class A member 3

1

4

High-throughput

0.489

High

1030179

PLGT2
Protein O-glucosyltransferase 2

1

1

High-throughput

0.489

High

1030180

ARSK
Arylsulfatase K

1

4

High-throughput

0.489

High

1030187

P3H3
Prolyl 3-hydroxylase 3

1

1

High-throughput

0.489

High

1030190

WDTC1
WD and tetratricopeptide repeats protein 1

1

8

High-throughput

0.489

High

1030192

PGLT1
Protein O-glucosyltransferase 1

1

1

High-throughput

0.489

High

1030193

TTC13
Tetratricopeptide repeat protein 13

1

1

High-throughput

0.489

High

1030195

UXS1
UDP-glucuronic acid decarboxylase 1

1

1

High-throughput

0.489

High

1030201

SC65
Endoplasmic reticulum protein SC65

1

1

High-throughput

0.489

High

1030204

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

High-throughput

0.489

High

1030215

TOR3A
Torsin-3A

1

2

High-throughput

0.489

High

1030221

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

1

2

High-throughput

0.489

High

1030223

P4HTM
Transmembrane prolyl 4-hydroxylase

1

1

High-throughput

0.489

High

1030227

SUN2
SUN domain-containing protein 2

1

1

High-throughput

0.489

High

1030230

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

1

High-throughput

0.489

High

1030232

MA2B2
Epididymis-specific alpha-mannosidase

1

3

High-throughput

0.489

High

987549

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.479

High

343579

OXSR1
Serine/threonine-protein kinase OSR1

1

7

High-throughput

0.445

High

607919

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

1

High-throughput

0.445

High

1030169

ERC6L
DNA excision repair protein ERCC-6-like

1

4

High-throughput

0.445

High

1030181

UN13D
Protein unc-13 homolog D

1

2

High-throughput

0.445

High

1030220

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.426

High

716109

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

1

High-throughput

0.407

High

1030166

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

1

High-throughput

0.407

High

1030170

SMTL2
Smoothelin-like protein 2

1

10

High-throughput

0.407

High

1030218

SYSM
Serine--tRNA ligase, mitochondrial

1

1

High-throughput

0.407

High

359806

DYR
Dihydrofolate reductase

1

0

High-throughput

0.279

Low

771659

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.279

Low

1030171

OFUT4
GDP-fucose protein O-fucosyltransferase 4

1

0

High-throughput

0.279

Low

1030183

OAF
Out at first protein homolog

1

0

High-throughput

0.279

Low

1030188

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.279

Low

1030208

NAR5
Ecto-ADP-ribosyltransferase 5

1

0

High-throughput

0.279

Low

1030224

SELN
Selenoprotein N

1

0

High-throughput

0.279

Low

329249

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.232

Low

358883

AL1A1
Aldehyde dehydrogenase 1A1

1

0

High-throughput

0.232

Low

663355

KTHY
Thymidylate kinase

1

0

High-throughput

0.232

Low

851874

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.232

Low

1030153

AK1C1
Aldo-keto reductase family 1 member C1

1

0

High-throughput

0.232

Low

1030184

AACS
Acetoacetyl-CoA synthetase

1

0

High-throughput

0.232

Low

1030197

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.232

Low

1030216

ARMT1
Damage-control phosphatase ARMT1

1

0

High-throughput

0.232

Low

1030222

HPF1
Histone PARylation factor 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025