HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: NEK4 (P51957)
Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)
Gene: NEK4

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	25798074, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 841
+	Hs
		438015 HS90B_HUMAN (19-732): 0: 1059: 86.13		NEK4_HUMAN (1-841): 0: 617: 100.00
+	Hs
		432376 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT3_HUMAN (2-335): 2.72e-135: 413: 22.94
+	Hs
		431573 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT2_HUMAN (1-333): 1.36e-134: 411: 22.12
+	Hs
		431572 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT1_HUMAN (1-330): 8.38e-132: 403: 23.44
+	Rn
		812703 HS90A_RAT (1-732): 0: 1085: 97.95		AKT1_RAT (1-330): 1.85e-132: 405: 23.44
+	Mm
		432411 HS90A_MOUSE (1-732): 0: 1083: 97.82		AKT1_MOUSE (1-330): 1.93e-132: 405: 23.44
+	Hs
		432326 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6B2_HUMAN (6-405): 5.48e-130: 399: 21.79
+	Hs
		437928 HS90B_HUMAN (19-732): 0: 1059: 86.13		AKT2_HUMAN (1-333): 1.36e-134: 411: 22.12
+	Mm
		513660 HS90B_MOUSE (19-732): 0: 1063: 86.98		AKT1_MOUSE (1-330): 1.93e-132: 405: 23.44
+	Bt
		964601 HS90B_BOVIN (19-732): 0: 1059: 86.28		AKT1_BOVIN (1-331): 4.22e-132: 404: 23.37
+	Hs
		437927 HS90B_HUMAN (19-732): 0: 1059: 86.13		AKT1_HUMAN (1-330): 8.38e-132: 403: 23.44
+	Hs
		431873 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A2_HUMAN (4-323): 1.89e-102: 335: 21.75
+	Hs
		438190 HS90B_HUMAN (19-732): 0: 1059: 86.13		KS6A2_HUMAN (4-323): 1.89e-102: 335: 21.75
+	Hs
		432077 HS90A_HUMAN (1-732): 0: 1087: 100.00		NEK11_HUMAN (6-265): 1.06e-60: 219: 43.02
+	Hs
		432008 HS90A_HUMAN (1-732): 0: 1087: 100.00		NEK8_HUMAN (3-313): 8.4e-60: 218: 37.14
+	Hs
		432092 HS90A_HUMAN (1-732): 0: 1087: 100.00		NEK9_HUMAN (6-330): 1.51e-56: 212: 36.78
+	Hs
		438369 HS90B_HUMAN (19-732): 0: 1059: 86.13		NEK11_HUMAN (6-265): 1.06e-60: 219: 43.02
+	Hs
		438311 HS90B_HUMAN (19-732): 0: 1059: 86.13		NEK8_HUMAN (3-313): 8.4e-60: 218: 37.14
+	Hs
		438014 HS90B_HUMAN (19-732): 0: 1059: 86.13		NEK2_HUMAN (6-261): 2.63e-48: 179: 40.91
+	Hs
		432294 HS90A_HUMAN (1-732): 0: 1087: 100.00		STK36_HUMAN (3-270): 7e-36: 149: 33.21