HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 0.60 0.697

The method score is based on:

Property Details
Experiments 26517842, 19802386, 20668552, 18538669
Identification Methods two hybrid, affinity chromatography technology, pull down, surface plasmon resonance
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0019901 - protein kinase binding
and 3 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 724
Hs

1 826
+ Hs
+ Mm
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+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Rn
+ Hs
+ Hs
+ Mm
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+ Hs
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+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024