HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: STA5A (P42229)
Signal transducer and activator of transcription 5A
Gene: STAT5A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	12456798
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, STAT_alpha~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1382 Hs			1 794
+	Hs
		439687 INSR_HUMAN (1-1382): 0: 1513: 100.00		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Rn
		98899 INSR_RAT (1-1382): 0: 1513: 94.29		F1M9D6_RAT (1-724): 0: 758: 28.26
+	Hs
		439673 INSR_HUMAN (1-1382): 0: 1513: 100.00		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		465440 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		907260 EPHA4_HUMAN (521-1352): 0: 576: 21.14		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		827721 EPHA5_HUMAN (521-1319): 0: 575: 22.17		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		411612 NTRK1_HUMAN (996-1286): 9.2e-68: 247: 42.62		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		913123 EPHB4_HUMAN (529-1318): 3.52e-174: 546: 20.91		STAT2_HUMAN (1-773): 0: 689: 24.07
+	Hs
		411518 NTRK1_HUMAN (996-1286): 9.2e-68: 247: 42.62		STAT1_HUMAN (1-724): 0: 755: 28.09
+	Hs
		827964 ALK_HUMAN (982-1339): 1.97e-70: 263: 40.53		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		411504 NTRK1_HUMAN (996-1286): 9.2e-68: 247: 42.62		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		650073 FGFR3_HUMAN (1015-1287): 2.22e-62: 231: 40.78		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		410685 ERBB2_HUMAN (32-343): 3.5e-21: 102: 20.74		STAT1_HUMAN (1-724): 0: 755: 28.09
+	Hs
		410680 ERBB2_HUMAN (32-343): 3.5e-21: 102: 20.74		STAT3_HUMAN (1-723): 0: 736: 29.94