HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	25065853
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 770
+	Hs
		827721 EPHA5_HUMAN (1-777): 0: 621: 20.18		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		411504 NTRK1_HUMAN (158-756): 6.61e-146: 449: 27.02		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		532052 KIT_HUMAN (19-794): 5.82e-166: 507: 24.62		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		411518 NTRK1_HUMAN (158-756): 6.61e-146: 449: 27.02		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		463916 RET_HUMAN (453-801): 9.75e-98: 330: 48.63		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		907260 EPHA4_HUMAN (1-781): 0: 619: 20.78		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		913123 EPHB4_HUMAN (3-786): 9.74e-179: 541: 17.92		STAT2_HUMAN (1-728): 0: 786: 38.47
+	Mm
		838277 TIE2_MOUSE (478-783): 1.06e-71: 257: 44.44		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		532064 KIT_HUMAN (19-794): 5.82e-166: 507: 24.62		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		532053 KIT_HUMAN (19-794): 5.82e-166: 507: 24.62		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		411612 NTRK1_HUMAN (158-756): 6.61e-146: 449: 27.02		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		778032 VGFR2_HUMAN (5-342): 3.96e-17: 88.6: 16.32		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		609957 VGFR1_HUMAN (40-357): 4.88e-13: 75.2: 13.25		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		541379 FGFR1_HUMAN (1-114): 5.62e-13: 74.7: 18.32		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		641133 FGFR2_HUMAN (1-137): 5.98e-11: 68.2: 18.18		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Mm
		777815 VGFR3_MOUSE (49-372): 2.91e-10: 66.3: 15.46		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		778033 VGFR2_HUMAN (5-342): 3.96e-17: 88.6: 16.32		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		609959 VGFR1_HUMAN (40-357): 4.88e-13: 75.2: 13.25		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		641140 FGFR2_HUMAN (1-137): 5.98e-11: 68.2: 18.18		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		641136 FGFR2_HUMAN (1-137): 5.98e-11: 68.2: 18.18		STA5A_HUMAN (1-734): 0: 745: 30.42