HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: SH2B1 (Q9NRF2)
SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)
Gene: SH2B1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.876

Property	Details
Experiments	9742218, 10594240, 15767667
Identification Methods	affinity chromatography technology, two hybrid, pull down, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SH2~fn3, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0045840 - positive regulation of mitotic nuclear division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 756
+	Hs
		145966 INSR_HUMAN (1-1382): 0: 1530: 100.00		SH2B2_HUMAN (25-755): 5.52e-128: 396: 35.11
+	Mm
		546279 INSR_MOUSE (1-1382): 0: 1509: 94.36		SH2B2_MOUSE (25-755): 2.98e-133: 409: 34.47
+	Rn
		292434 T2CB11_RAT (1-1382): 0: 1538: 94.87		GRB14_RAT (76-617): 1.12e-117: 366: 15.02
+	Rn
		292431 INSR_RAT (1-1382): 0: 1527: 94.44		GRB14_RAT (76-617): 1.12e-117: 366: 15.02
+	Hs
		411383 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB14_HUMAN (76-627): 1.9e-115: 361: 14.19
+	Hs
		411312 INSR_HUMAN (1-1382): 0: 1530: 100.00		SHC1_HUMAN (52-627): 2.87e-100: 322: 17.54
+	Hs
		411376 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB10_HUMAN (82-618): 1.38e-92: 302: 12.05
+	Hs
		411288 INSR_HUMAN (1-1382): 0: 1530: 100.00		VAV_HUMAN (40-685): 2.92e-87: 295: 13.46
+	Hs
		411384 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB7_HUMAN (99-613): 1.08e-80: 269: 12.89
+	Mm
		546274 INSR_MOUSE (1-1382): 0: 1509: 94.36		GRB10_MOUSE (110-618): 3.47e-84: 281: 11.93
+	Hs
		411292 INSR_HUMAN (1-1382): 0: 1530: 100.00		PLCG1_HUMAN (451-753): 3.41e-69: 249: 17.19
+	Rn
		499158 INSR_RAT (1-1382): 0: 1527: 94.44		PLCG1_RAT (451-753): 2.19e-69: 250: 17.50
+	Mm
		403410 INSR_MOUSE (1-1382): 0: 1509: 94.36		SRC_MOUSE (376-742): 2.81e-73: 249: 13.68
+	Hs
		435550 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		SHC1_HUMAN (52-627): 2.87e-100: 322: 17.54
+	Hs
		411329 INSR_HUMAN (1-1382): 0: 1530: 100.00		CSK_HUMAN (514-607): 2.67e-35: 141: 29.79
+	Hs
		411352 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB2_HUMAN (517-646): 2.75e-16: 80.5: 18.46
+	Hs
		435518 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		SRC_HUMAN (376-742): 1.26e-71: 245: 13.88
+	Hs
		435570 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		CSK_HUMAN (514-607): 2.67e-35: 141: 29.79
+	Hs
		435573 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		MATK_HUMAN (439-604): 3.53e-23: 105: 21.18
+	Hs
		435602 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		GRB2_HUMAN (517-646): 2.75e-16: 80.5: 18.46